Megacin125mg/5ml

Indication

Pneumonia, Pharyngitis, Susceptible infections, Otitis media, Skin and Skin-Structure Infections, Rheumatic fever, Tonsillitis, Respiratory tract infect... View More

Administration

May be taken with or without food. May be taken w/ meals to reduce GI discomfort. Parenteral doses by deep IM or slow IV inj over 3-5 min or by IV in... View More

Adult Dose

Adult: PO Susceptible infections 1-2 g/day in 2-4 divided doses. Max: 4 g/day. Surgical prophylaxis 1-2 g pre-op. Subsequent doses may be given as nee... View More

Child Dose

Children: Oral: The usual total dose is 25 to 50 mg/kg/day given in 2 to 4 equally divided doses. Injection: 50 to 100 mg/kg/day in 4 equally divide... View More

Renal Dose

Renal impairment: For patients undergoing chronic intermittent haemodialysis: 250 mg may be given at the start of the session, repeated after 6-12 hr, t... View More

Contraindication

Hypersensitivity to cefradine or other cephalosporins; porphyria.

Mode of Action

Cefradine is a 1st generation cephalosporin which inhibits the final transpeptidation step of the peptidoglycan synthesis in bacterial cell wall by bind... View More

Precaution

Renal impairment; history of penicillin sensitivity; pregnancy; lactation.

Side Effect

Diarrhoea, nausea, vomiting; leukopenia, neutropenia, eosinophilia, rash, pruritus; joint pain; increased BUN and creatine; dizziness. Potentially Fa... View More

Interaction

Increased risk of nephrotoxicity w/ loop diuretics. Decreased renal clearance w/ probenecid.