It is not known whether it is safe to consume alcohol with Naurif 1. Please consult your doctor.
SAFE IF PRESCRIBED
Naurif 1 is generally considered safe to use during pregnancy. Animal studies have shown low or no adverse effects to the developing baby; however, there are limited human studies.
SAFE IF PRESCRIBED
Naurif 1 is probably safe to use during breastfeeding. Limited human data suggests that the drug does not represent any significant risk to the baby.
SAFE
Naurif 1 does not usually affect your ability to drive.
SAFE IF PRESCRIBED
Naurif 1 is probably safe to use in patients with kidney disease. Limited data available suggests that dose adjustment of Naurif 1 may not be needed in these patients. Please consult your doctor.
SAFE IF PRESCRIBED
Naurif 1 is probably safe to use in patients with liver disease. Limited data available suggests that dose adjustment of Naurif 1 may not be needed in these patients. Please consult your doctor.
Medicine Overview of Naurif 1mg Tablet
Introduction
Naurif 1 is an antiemetic medicine commonly used to control nausea and vomiting due to certain medical conditions like stomach upset. It is also used to prevent nausea and vomiting caused due to any surgery, cancer drug therapy or radiotherapy.
Naurif 1 will not relieve other side effects associated with cancer treatments. It also has little effect on vomiting caused by motion sickness. You should take this medicine in the dose and duration advised by your doctor. But, it is better to take this medicine at a fixed time. Remember, you should not stop taking this medicine suddenly without talking to your doctor. In case you vomit within one hour of taking a dose, then take another dose and avoid heavy meals throughout the day.
The most common side effects of taking this medicine include headache, constipation, diarrhea and weakness. Dizziness and sleepiness may also occur, so do not drive or do anything that requires mental focus until you know how this medicine affects you. These symptoms should disappear when you stop taking the medicine but if they bother you or do not go away, your doctor may be able to suggest ways of preventing or reducing them.
Before taking this medicine, tell your doctor if you have heart or liver problems or a blockage in your stomach or intestines. Also, tell your doctor about any other medicine that you might be using, especially medicines to treat epilepsy, heart problems, cancer and depression. These may affect, or be affected by, this medicine. If you are pregnant or breastfeeding, ask for advice from your healthcare team.
Uses of Naurif 1
Nausea
Vomiting
Side effects of Naurif 1
Common
Sleepiness
Weakness
Headache
Constipation
Diarrhea
How to use Naurif 1
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Naurif 1 may be taken with or without food, but it is better to take it at a fixed time.
How Naurif 1 works
Naurif 1 is an antiemetic medication. It works by blocking the action of a chemical messenger (serotonin) in the brain that may cause nausea and vomiting during anti-cancer treatment (chemotherapy) or after surgery.
What if you forget to take Naurif 1?
If you miss a dose of Naurif 1, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
Quick Tips
You have been prescribed Naurif 1 for prevention of nausea and vomiting caused after surgery or due to chemotherapy and radiotherapy.
Unlike some other nausea medicines, the side effects for Naurif 1 are relatively mild.
It is fast-acting and starts working within 30 minutes.
If you vomit within one hour of taking a dose, take another dose.
Avoid heavy meals and try eating small nourishing snacks throughout the day. Also, sip water regularly to help avoid dehydration.
Brief Description
Indication
Nausea and vomiting, Chemotherapy-induced nausea and vomiting, Post-operative nausea and vomiting
Administration
May be taken with or without food. Take up to 1 hr before chemotherapy.
Adult Dose
Chemotherapy Induced Nausea & Vomiting
Oral
1 mg PO 1 hr before chemotherapy, then 1 mg 12 hr after 1st dose; OR 2 mg 1 hr before chemotherapy
IV
0.01 mg/kg/dose infused over 5 min or direct injected over 30 sec, 30 min before chemotherapy
Radiation-Induced Nausea & Vomiting
2 mg PO, 1 hr before radiation treatment
Postoperative Nausea & Vomiting
Prevention: 1 mg (undiluted) IV push over 30 seconds; administer before anesthetic induction or immediately before reversal of anesthesia
Treatment: 1 mg (undiluted) IV push over 30 seconds
Elderly:
Chemotherapy Induced Nausea & Vomiting
Oral: 2 mg 1 hr before chemotherapy, then 1 mg 12 hr after 1st dose; OR 2 mg 1 hr before chemo
IV: 0.01 mg/kg/dose infused over 5 min or direct injected over 30 sec, 30 min before chemotherapy
Radiation-Induced Nausea & Vomiting
2 mg PO, 1 hr before radiation treatment
Postoperative Nausea & Vomiting
Prevention: 1 mg (undiluted) IV push over 30 seconds; administer before anesthetic induction or immediately before reversal of anesthesia
Treatment: 1 mg (undiluted) IV push over 30 seconds
Hepatic impairment
No dosage adjustment required
Child Dose
Chemotherapy Induced Nausea & Vomiting
<2 years: Safey and efficacy not established
2-16 years: As adults; 0.01 mg/kg infused over 5 min or direct inj over 30 sec, 30 min before chemotherapy
Oral administration: Currently FDA-approved for IV administration in children; safety and efficacy of oral administration is not established
Postoperative Nausea & Vomiting
Safety and efficacy not established
Not approved for postoperative N/V in pediatric patients because of lack of efficacy and QT prolongation observed in clinical trials
Renal Dose
Renal impairment
IV
Severe (CrCl <30 mL/min): Total clearance was not affected in patients with severe renal failure who received a single 40 mcg/kg IV dose
PO
No dosage adjustment required
Contraindication
Hypersensitivity.
Mode of Action
Granisetron is a selective 5-HT3-receptor antagonist with little or no affinity for other serotonin receptors. It blocks serotonin in the chemoreceptor zone.
Precaution
Subacute intestinal obstruction or ileus. Moderate to severe hepatic impairment. Congenital long QT syndrome or other risk factors for QT prolongation (e.g. electrolyte abnormalities and cumulative high-dose anthracycline therapy). Pregnancy, lactation.
Lactation: excretion in milk unknown; use with caution
Side Effect
>10%
Headache (10-21%)
1-10%
Diarrhea (1-9%),Constipation (3-18%),Asthenia (5%),Somnolence (10%),Sedation (10%),Drowsiness (10%)
Frequency Not Defined
Anxiety,Fatigue,Malaise,Increased LFTs
Interaction
Phenobarbital may induce metabolism of granisetron.
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The information provided herein is accurate, updated and complete as per the best practices of the Company. Please note that this information should not be treated as a replacement for physical medical consultation or advice. We do not guarantee the accuracy and the completeness of the information so provided. The absence of any information and/or warning to any drug shall not be considered and assumed as an implied assurance of the Company. We do not take any responsibility for the consequences arising out of the aforementioned information and strongly recommend you for a physical consultation in case of any queries or doubts.