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Square Pharmaceuticals Ltd.
Generic: Procyclidine Hydrochloride
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descriptionSafety Advices
Perkinil may cause excessive drowsiness with alcohol.
Perkinil may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developin... View More
Perkinil should be used with caution during breastfeeding. Breastfeeding should be held until the treatment of the mother is completed and the drug is e... View More
Perkinil may decrease alertness, affect your vision or make you feel sleepy and dizzy. Do not drive if these symptoms occur.
Perkinil should be used with caution in patients with kidney disease. Dose adjustment of Perkinil may be needed. Please consult your doctor.
Perkinil should be used with caution in patients with liver disease. Dose adjustment of Perkinil may be needed. Please consult your doctor.
descriptionMedical Overview


Perkinil is a prescription medicine used in the treatment of Parkinson's disease and drug induced abnormal movements. It helps by improving muscle contr... View More

Uses of Perkinil

  • Parkinson's disease

Side effects of Perkinil

  • Dryness in mouth
  • Nausea
  • Vomiting
  • Constipation
  • Blurred vision
  • Dizziness
  • Lightheadedness
  • Dilatation of pupil
  • Upper abdominal pain
  • Urinary retention

How to use Perkinil

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Perkinil is to be taken wi... View More

How Perkinil works

Perkinil is a muscle relaxing medication. It works by decreasing the activity of excess acetylcholine in the brain. This improves muscle control and red... View More

quick tipsQuick Tips
  • Perkinil helps treat Parkinson's disease and drug-induced abnormal movements.
  • Dry mouth may occur as a side effect. Frequent mouth rinses, good oral hygiene, increased water intake and sugarless candy may help.
  • It may cause dry eyes. Avoid wearing contact lenses and inform your doctor if it bothers you.
  • It may cause dizziness and sleepiness. Do not drive or do anything requiring concentration until you know how it affects you.
  • Inform your doctor if you suffer from glaucoma or if you have trouble passing urine.
  • Do not stop taking Perkinil without talking to your doctor first as that may cause worsening of symptoms.
  • Monitoring of intraocular pressure is required while taking this medicine, as an increase in eye pressure may cause blurry vision.
  • You may be asked for regular monitoring of hypotension, kidney, liver, and cardiac disorder while taking this medicine.
descriptionBrief Description


Parkinsonism, Drug-induced extrapyramidal syndrome

Adult Dose

Oral Parkinsonism and drug-induced extrapyramidal syndrome Adult: As hydrochloride: Initially, 2.5 mg tid, increased gradually by 2.5-5 mg every 2-3 d... View More

Child Dose

Oral Dystonia in children Child: 7-12 yr: 1.25 mg tid; 12-18 yr: 2.5 mg tid. For emergency cases, a single dose may be given via IM or IV inj: <... View More


Urinary outflow obstruction, prostatic hyperthrophy, narrow-angle glaucoma, paralytic ileus and pyloric stenosis.

Mode of Action

Procyclidine is a tertiary amine antimuscarinic which acts by blocking excess acetylcholine at cerebral synapses. It also exhibits direct antispasmodic ... View More


Patient w/ mental disorders, CV disease (e.g. tachycardia, cardiac arrhythmias, hypertention, hypotension). Hepatic and renal impairment. Avoid abrupt w... View More

Side Effect

Dry mouth, mydriasis, blurred vision, lightheadedness, giddiness, disorientation, GI effects (e.g. nausea, vomiting, epigastric distress, constipation),... View More


Increased plasma concentrations w/ paroxetine. Enhanced anticholinergic action w/ MAOIs and other anticholinergic drugs. Reduced therapeutic effect w/ c... View More

Alternative brand for Perkinil
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The information provided herein is accurate, updated and complete as per the best practices of the Company. Please note that this information should not... View More