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Piozena Plus 500
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Piozena Plus 500500mg+15mg

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Drug International Ltd.
Generic: Metformin Hydrochloride + Pioglitazone
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descriptionSafety Advices
It is unsafe to consume alcohol with Piozena Plus 500.
Piozena Plus 500 may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the d... View More
Piozena Plus 500 is probably safe to use during breastfeeding. Limited human data suggests that the drug does not represent any significant risk to the ... View More
Your ability to drive may be affected if your blood sugar is too low or too high. Do not drive if these symptoms occur.
Piozena Plus 500 should be used with caution in patients with kidney disease. Dose adjustment of Piozena Plus 500 may be needed. Please consult your doc... View More
Piozena Plus 500 should be used with caution in patients with liver disease. Dose adjustment of Piozena Plus 500 may be needed. Please consult your doct... View More
descriptionMedical Overview


Piozena Plus 500 is a combination medicine that helps control blood sugar levels. This medicine is used together with diet and exercise to improve blood... View More

Uses of Piozena Plus 500

  • Type 2 diabetes mellitus

Side effects of Piozena Plus 500

  • Nausea
  • Loss of appetite
  • Taste change
  • Stomach pain
  • Diarrhea
  • Edema (swelling)
  • Weight gain
  • Respiratory tract infection
  • Bone fracture
  • Blurred vision

How to use Piozena Plus 500

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Piozena Plus 500 is to be ... View More

How Piozena Plus 500 works

Piozena Plus 500 is a combination of two antidiabetic medicines: Pioglitazone and metformin. Pioglitazone is a thiazolidinedione which works by increasi... View More

quick tipsQuick Tips
  • Take it as per the dose and duration prescribed by your doctor.
  • Monitor your blood sugar level regularly while you are taking this medicine.
  • It can cause hypoglycemia (low blood sugar level) when used with other antidiabetic medicines, alcohol or if you delay or miss a meal.
  • Always carry some sugary food or fruit juice with you in case you experience hypoglycemic symptoms such as cold sweats, cool pale skin, tremor, and anxi... View More
  • Your doctor may check your liver function regularly. Inform your doctor if you develop symptoms such as abdominal pain, loss of appetite, or yellowing o... View More
  • Inform your doctor if you notice weight gain, shortness of breath, irregular heartbeat, or any abnormal swelling.
descriptionBrief Description


Type 2 DM

Adult Dose

Oral Type 2 diabetes mellitus Adult: Tab contains pioglitazone 15 mg and metformin 500 mg or 850 mg: Initially, 15 mg/500 mg bid or 15 mg/850 mg on... View More

Child Dose

Safety and efficacy not established

Renal Dose

Renal impairment Obtain eGFR before starting metformin eGFR <30 mL/min/1.73 m²: Contraindicated eGFR 30-45 mL/min/1.73 m²: Not recommended to initiat... View More


Renal disease or renal dysfunction (e.g. as suggested by serum creatinine levels >1.5 mg/dl in male, >1.4 mg/dl in females or abnormal creatinine cleara... View More

Mode of Action

Pioglitazone is as a potent and highly selective agonist for the peroxisome proliferator activated receptor-gamma. Activation of these receptors promote... View More


Patient w/ oedema, anaemia. Premenopausal, anovulatory women. Pregnancy. Patient Counselling This drug may cause visual disturbance, if affected, do not... View More

Side Effect

>10% Lower limb edema (2.9-11.3%),Upper respiratory infection (12-16) 1-10% Weight gain (2.9-6.7%),Diarrhea (4.8-5.8%),Nausea (3.6-5.8%),Urinary tr... View More


Additive effect w/ sulfonylureas. Thiazide diuretics, corticosteroids, phenothiazines, OC, sympathomimetics, niacin, Ca channel blockers and isoniazid m... View More

Alternative brand for Piozena Plus 500
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The information provided herein is accurate, updated and complete as per the best practices of the Company. Please note that this information should not... View More

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