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Generic: Denosumab
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descriptionSafety Advices
Caution is advised when consuming alcohol with Prolia. Please consult your doctor.
Prolia is highly unsafe to use during pregnancy. Seek your doctor's advice as studies on pregnant women and animals have shown significant harmful effec... View More
Prolia is probably safe to use during breastfeeding. Limited human data suggests that the drug does not represent any significant risk to the baby.
Prolia does not usually affect your ability to drive.
Prolia is safe to use in patients with kidney disease. No dose adjustment of Prolia is recommended.
Prolia is probably safe to use in patients with liver disease. Limited data available suggests that dose adjustment of Prolia may not be needed in these... View More
descriptionMedical Overview


Prolia is a medicine used in the treatment of osteoporosis in postmenopausal women and in men at increased risk of fractures. It makes the bones strong ... View More

Uses of Prolia

  • Osteoporosis

Side effects of Prolia

  • Musculoskeletal (bone, muscle or joint) pain
  • Pain in extremity
  • Nerve pain
  • Constipation
  • Rash
  • Urinary tract infection

How to use Prolia

Your doctor or nurse will guide you how to use this medicine.

How Prolia works

Prolia is a monoclonal antibody. It binds to a protein that causes bone loss, thereby strengthening the bone and minimizing the risk of fractures.

What if you forget to take Prolia?

If you miss a dose of Prolia, please consult your doctor.

quick tipsQuick Tips
  • Xgeva Solution for Injection is a medication used to treat thinning of the bones (called osteoporosis).
  • Take calcium and vitamin D to help build your bones when taking Xgeva Solution for Injection.
  • Do not take if you are pregnant or plan to become pregnant.
  • May cause a rare problem of the jaw (osteonecrosis), mostly seen after a dental procedure. Tell your doctor if you develop sudden jaw pain.
  • Xgeva Solution for Injection may also increase the risk of infection. Avoid being close to people with cold, flu or other contagious illnesses.
  • Tell your doctor if you develop a rash while taking Xgeva Solution for Injection.
descriptionBrief Description


Osteoporosis, treatment of men and postmenopausal women with osteoporosis who are at high risk for fracture; treatment to increase bone mass in men at h... View More


Administer SC in upper arm, upper thigh, or abdomen; do NOT administer intradermally, IM, or IV Administer calcium and vitamin D as needed to treat or ... View More

Adult Dose

Denosumab 60mg Subcutaneous Osteoporosis 60 mg SC every 6 months Supplement with calcium 1000 mg/day and vitamin D 400 IU/day Aromatase Inhibitor... View More

Renal Dose

Renal Impairment: Based on the available safety and efficacy data in the elderly, no dosage adjustment is required in patients with renal impairment. P... View More


Clinically significant hypersensitivity to denosumab or to any of the components. Hypocalcemia.

Mode of Action

Denosumab is a human monoclonal antibody (IgG2) that targets and binds with high affinity and specificity to receptor activator of nuclear factor kappa-... View More


Correct hypocalcemia prior to initiation of therapy. Patients should receive Ca & vit D supplements during treatment (unless hypercalcemia is present). ... View More

Side Effect

>10% Back pain (34.7%),Extremity pain (11.7%) 1-10% Musculoskeletal pain (7.6%),Hypercholesterolemia (7.2%),Cystitis (5.9%),Upper respiratory tract... View More

Pregnancy Category Note

Pregnancy Contraindicated Based on findings in animals and its mechanism of action, denosumab can cause fetal harm when administered to a pregnant w... View More


Increased risk of serious infections w/ immunosuppressive agents.Denosumab did not affect the pharmacokinetics of midazolam, a drug metabolised by cytoc... View More

Alternative brand for Prolia
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The information provided herein is accurate, updated and complete as per the best practices of the Company. Please note that this information should not... View More

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