Introduction
Protogyn is an antibiotic medicine that helps your body fight infections caused by bacteria and parasites. It is used to treat infections of the liver, stomach, intestines, vagina, brain, heart, lungs, and skin.
Protogyn is also used in the treatment of dental infections, leg ulcers and pressure sores. This medicine should be taken with food, at the same time each day to get the most benefit. The amount you are advised will depend on what you are being treated for and how bad it is, but you should take this antibiotic exactly as prescribed by your doctor. Your symptoms may get better after a short time but do not stop taking it until you have finished a full course of treatment, even if you feel well. If you stop taking it early, some bacteria may survive, and the infection may come back. Do not drink any alcohol while taking this medicine and for some days after stopping it. Otherwise, you may get unpleasant side effects like nausea, vomiting and stomach pain.
The most common side effects of this medicine are headache, dryness in mouth, nausea, and a slight metallic taste in the mouth. These are usually mild but let your doctor know if they bother you or last more than a few days. You can try using sugarless candies or lozenges to overcome any dryness or metallic taste in the mouth.
Before using this medicine, inform your doctor if you are allergic to any medicine or have any kidney or liver problems or any disease of the nervous system. Your doctor may change the dose or prescribe a different medicine. This medicine should not be taken if you are pregnant or breastfeeding unless it is absolutely necessary and prescribed by your doctor.
Uses of Protogyn
- Bacterial infections
- Parasitic infections
Side effects of Protogyn
Common
- Headache
- Dryness in mouth
- Nausea
- Metallic taste
How to use Protogyn
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Protogyn is to be taken with food.
How Protogyn works
Protogyn is an antibiotic. It kills the bacteria and other microorganisms that cause infections by damaging their DNA.
What if you forget to take Protogyn?
If you miss a dose of Protogyn, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
Indication
Giardiasis, H. pylori infection, Surgical Prophylaxis, Bacterial vaginosis, Intestinal amoebiasis, Trichomoniasis, Acute necrotising ulcerative gingivitis, Hepatic amoebiasis
Administration
Should be taken with food. Take during or immediately after meals.
Adult Dose
Oral
Bacterial vaginosis
Adult: 2 g as single dose. May also be given as 2 g for 2 consecutive days or 1 g daily for 5 days.
Anaerobic bacterial infections
Adult: 2 g on the 1st day, followed by 1 g daily or 500 mg bid for 5-6 days.
Prophylaxis of postoperative anaerobic bacterial infections
Adult: 2 g as single dose 12 hr before surgery.
Eradication of H. pylori associated with peptic ulcer disease
Adult: 500 mg bid, given w/ clarithromycin and omeprazole for 7 days.
Intestinal amoebiasis
Adult: 2 g daily for 2 or 3 days.
Hepatic amoebiasis
Adult: 1.5-2 g daily for 3-6 days.
Giardiasis
Adult: 2 g as single dose.
Trichomoniasis; Acute necrotising ulcerative gingivitis
Adult: 2 g as single dose. In trichomoniasis, sexual partners should be treated at the same time.
Intravenous
IV Susceptible infections
Initial: Infuse 800 mg, followed by 800 mg/day or 400 mg twice daily till PO can be given.
Surgical prophylaxis
1.6 g as single infusion pre-op.
Child Dose
Oral
Intestinal amoebiasis
Child: >3 yr 50-60 mg/kg daily for 3 consecutive days. Max: 2 g/day.
Hepatic amoebiasis
Child: >3 yr 50-60 mg/kg daily for 5 days. Max: 2 g/day.
Giardiasis
Child: >3 yr 50-75 mg/kg as single dose, repeat if necessary. Max: 2 g/day.
Renal Dose
Renal impairment: Haemodialysis: Additional dose equal to half the usual dose at the end of haemodialysis.
Contraindication
Blood dyscrasias, organic neurologic disorders, hypersensitivity to 5-nitroimidazole derivatives, porphyria. Lactation, pregnancy (1st trimester).
Mode of Action
Tinidazole, a 5-nitroimidazole derivative w/ antimicrobial actions similar to metronidazole, is active against both protozoa (e.g. Trichomonas vaginalis, Entamoeba histolytica and Giardia lamblia) and obligate anaerobic bacteria. It damages DNA strands or inhibits DNA synthesis in microorganism.
Precaution
Patient w/ current or a history of blood dyscrasias. Pregnancy (2nd and 3rd trimester). Hepatic and renal impairment. Monitoring Parameters Monitor total and differential leukocyte counts. Closely monitor childn when treatment duration exceeds 3 days.
Lactation: discontinue nursing while taking drug & for 3 d after last dose
Side Effect
1-10%
Anorexia (2-3%),Constipation (<1%),Dizziness (<1%),Dysgeusia (4-6%),Dyspepsia (1-2%),Headache (<1%),Nausea (3-5%),Vomiting (1-2%),Weakness/fatigue/malaise (1-2%)
Frequency Not Defined
Ataxia,Candida overgrowth,Convulsions & transient peripheral neuropathy,Numbness & paresthesia,Diarrhea,Darkened urine,Tongue discoloration,Transient leukopenia/neutropenia
Potentially Fatal: Hypersensitivity.
Interaction
May potentiate the effects of oral anticoagulants resulting to prolonged prothrombin time.