Purinethol is used in the treatment of blood cancer. It shows its working by decreasing the number of red blood cells, which is produced by the body. P... View More
Uses of Purinethol
Side effects of Purinethol
How to use Purinethol
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Purinethol may be taken wi... View More
How Purinethol works
Purinethol interferes with the growth of DNA and RNA of the cancer cells by substituting their building blocks. It prevents the cancer cells from growin... View More
Acute lymphatic leukaemia, Crohn's disease
Should be taken on an empty stomach. Best taken on an empty stomach 1 hr before or 2 hr after meals. Ensure adequate fluid intake.
Acute Lymphatic Leukemia Induction: 2.5 mg/kg PO qDay; usually 100-200 mg PO qDay in average adult (other agents preferred) May increase by 5 mg/kg/d... View More
Acute Lymphatic Leukemia Starting dose: 1.25-2.5 mg/kg (50-75 mg/m²) PO qDay Maintenance: 1.5-2.5 mg/kg PO qDay in combination with methotrexate
Renal Impairment: Dosage may need to be reduced.
Pregnancy and lactation. Prior resistance to mercaptopurine or thioguanine; severe liver disease; severe bone marrow suppression.
Mode of Action
Mercaptopurine is a purine antagonist which is converted intracellularly into its active nucleotides, including thioinosinic acid. The nucleotides inhib... View More
Hepatic or renal dysfunction; monitor hepatic function periodically. Mercaptopurine is potentially carcinogenic. Thiopurine S-methyl transferase (TPMT) ... View More
>10% Elevated LFT's (15%) 1-10% Nausea (10%),Vomiting (10%),Stomatitis (3-10%),Thrombocytopenia (3-10%),Rash (1-3%),Diarrhea (1-3%),Dizziness (1-3%... View More
Anticoagulant action of warfarin may be inhibited by mercaptopurine. Enhanced toxicity with myelosuppressive drugs. Potentially Fatal: Effects enhanc... View More
The information provided herein is accurate, updated and complete as per the best practices of the Company. Please note that this information should not... View More