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Purinethol
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Purinethol50mg

Tablet
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GlaxoSmithKline
Generic: Mercaptopurine
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36.68
MRP
40.76
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descriptionSafety Advices
AlcoholAlcohol
CONSULT YOUR DOCTOR
It is not known whether it is safe to consume alcohol with Purinethol. Please consult your doctor.
PregnancyPregnancy
CONSULT YOUR DOCTOR
Purinethol is unsafe to use during pregnancy as there is definite evidence of risk to the developing baby. However, the doctor may rarely prescribe it i... View More
BreastfeedingBreastfeeding
CONSULT YOUR DOCTOR
Purinethol is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.
DrivingDriving
SAFE
Purinethol does not usually affect your ability to drive.
KidneyKidney
CAUTION
Purinethol should be used with caution in patients with kidney disease. Dose adjustment of Purinethol may be needed. Please consult your doctor.
LiverLiver
CAUTION
Purinethol should be used with caution in patients with liver disease. Dose adjustment of Purinethol may be needed. Please consult your doctor. Inform y... View More
descriptionMedical Overview

Introduction

Purinethol is used in the treatment of blood cancer. It shows its working by decreasing the number of red blood cells, which is produced by the body. P... View More

Uses of Purinethol

  • Blood cancer

Side effects of Purinethol

Common
  • Nausea
  • Vomiting
  • Rash
  • Decreased white blood cell count (neutrophils)
  • Intestinal ulcer
  • Anemia (low number of red blood cells)
  • Increased bilirubin in the blood
  • Low blood platelets
  • Increased transaminase level in blood
  • Diarrhea
  • Loss of appetite

How to use Purinethol

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Purinethol may be taken wi... View More

How Purinethol works

Purinethol interferes with the growth of DNA and RNA of the cancer cells by substituting their building blocks. It prevents the cancer cells from growin... View More

quick tipsQuick Tips
  • Purinethol is used for the treatment of cancer of the blood.
  • Take it with or without food.
  • Do not drive or do anything requiring concentration until you know how it affects you.
  • Use a reliable contraceptive method to prevent pregnancy while you are taking this medicine.
  • Your doctor may get regular blood and urine tests done to monitor your blood cells, kidney and liver function during treatment with this medicine.
  • Inform your doctor immediately if you notice any signs of infection such as fever, sore throat, rash or severe diarrhea.
descriptionBrief Description

Indication

Acute lymphatic leukaemia, Crohn's disease

Administration

Should be taken on an empty stomach. Best taken on an empty stomach 1 hr before or 2 hr after meals. Ensure adequate fluid intake.

Adult Dose

Acute Lymphatic Leukemia Induction: 2.5 mg/kg PO qDay; usually 100-200 mg PO qDay in average adult (other agents preferred) May increase by 5 mg/kg/d... View More

Child Dose

Acute Lymphatic Leukemia Starting dose: 1.25-2.5 mg/kg (50-75 mg/m²) PO qDay Maintenance: 1.5-2.5 mg/kg PO qDay in combination with methotrexate

Renal Dose

Renal Impairment: Dosage may need to be reduced.

Contraindication

Pregnancy and lactation. Prior resistance to mercaptopurine or thioguanine; severe liver disease; severe bone marrow suppression.

Mode of Action

Mercaptopurine is a purine antagonist which is converted intracellularly into its active nucleotides, including thioinosinic acid. The nucleotides inhib... View More

Precaution

Hepatic or renal dysfunction; monitor hepatic function periodically. Mercaptopurine is potentially carcinogenic. Thiopurine S-methyl transferase (TPMT) ... View More

Side Effect

>10% Elevated LFT's (15%) 1-10% Nausea (10%),Vomiting (10%),Stomatitis (3-10%),Thrombocytopenia (3-10%),Rash (1-3%),Diarrhea (1-3%),Dizziness (1-3%... View More

Interaction

Anticoagulant action of warfarin may be inhibited by mercaptopurine. Enhanced toxicity with myelosuppressive drugs. Potentially Fatal: Effects enhanc... View More

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descriptionDisclaimer

The information provided herein is accurate, updated and complete as per the best practices of the Company. Please note that this information should not... View More

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