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Pyrison
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Pyrison25mg

Tablet
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Jayson Pharmaceuticals Ltd.
Generic: Pyrimethamine
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0.28
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descriptionMedical Overview

Indication

Acute malaria, Malaria prophylaxis, Toxoplasmosis

Administration

Should be taken with food.

Adult Dose

Oral Acute malaria Adult: As a single dose, in combination with a sulfonamide: 75 mg pyrimethamine with 1.5 g sulfadoxine. Prophylaxis of malaria ... View More

Child Dose

Oral Acute malaria Child: 7-13 yr: 50 mg pyrimethamine with 1 g sulfadoxine; 1-6 yr: 25 mg pyrimethamine with 500 mg sulfadoxine; 5-11 mth: 12.5 m... View More

Contraindication

Hypersensitivity, resistant malaria, megaloblastic anaemia secondary to folate deficiency. Pregnancy and lactation.

Mode of Action

Pyrimethamine is a folic acid antagonist structurally similar to trimethoprim. It inhibits parasitic dihydrofolate reductase, thus inhibiting vital tetr... View More

Precaution

Renal or hepatic impairment; folate deficiency; monitor blood and platelet counts every 2 wk with prolonged treatment and large doses. Discontinue use i... View More

Side Effect

Rashes, macrocytic anaemia (high dose), leucopenia, thrombocytopenia, megaloblastic anaemia, pancytopenia, abdominal pain, vomiting, atrophic glossitis.... View More

Interaction

Lorazepam may induce hepatotoxicity. Increased risk of bone marrow suppression when used with agents that have myelosuppressive properties e.g. proguani... View More

descriptionDisclaimer

The information provided herein is accurate, updated and complete as per the best practices of the Company. Please note that this information should not... View More

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