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Square Pharmaceuticals PLC.
Generic: Nalbuphine Hydrochloride
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descriptionSafety Advices
It is unsafe to consume alcohol with Radirif.
Radirif is generally considered safe to use during pregnancy. Animal studies have shown low or no adverse effects to the developing baby; however, there... View More
Radirif is probably safe to use during breastfeeding. Limited human data suggests that the drug does not represent any significant risk to the baby.
Radirif may decrease alertness, affect your vision or make you feel sleepy and dizzy. Do not drive if these symptoms occur.
Radirif should be used with caution in patients with kidney disease. Dose adjustment of Radirif may be needed. Please consult your doctor.
Radirif should be used with caution in patients with liver disease. Dose adjustment of Radirif may be needed. Please consult your doctor.
descriptionMedical Overview


Radirif is a pain relieving medicine. It is used to treat moderate to severe pain. It is also used as a premedication before surgery. This medicine is g... View More

Uses of Radirif

  • Moderate to severe pain

Side effects of Radirif

  • Headache
  • Dizziness
  • Sleepiness
  • Vomiting
  • Nausea
  • Constipation

How to use Radirif

Your doctor or nurse will give you this medicine. Kindly do not self administer.

How Radirif works

Radirif is an opioid analgesic (pain reliever) which works by blocking transmission of pain signals to the brain to lower pain perception.

What if you forget to take Radirif?

If you miss a dose of Radirif, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your r... View More

quick tipsQuick Tips
  • Use Radirif as instructed by your doctor. Never take in greater amounts or more often than prescribed.
  • It causes sleepiness or drowsiness. If this happens to you, do not drive or use machinery.
  • Avoid consuming alcohol when taking the Radirif, as it may cause excessive sleepiness or drowsiness.
  • Inform your doctor if you have ever been diagnosed with kidney or liver problems.
  • Store opioid pain relievers in a safe place and out of reach of others.
descriptionBrief Description


Moderate to severe pain, Pain associated with MI, Balanced anaesthesia


IV Administration Administer each 10 mg by IV push over 3-5 minutes

Adult Dose

Parenteral Moderate to severe pain Adult: IM/IV/SC: 10-20 mg 3-6 hrly as required. Non-opioid-tolerant patients: Max single dose: 20 mg. Max daily d... View More

Child Dose

Pain <1 year: Safety and efficacy not established >1 year: 0.1-0.2 mg/kg IV/IM/SC q3-4hr PRN; individual dose not to exceed 20 mg; not to exceed 160... View More

Renal Dose

Renal impairment: Caution; dose reduction may be necessary; monitor


Hypersensitivity. Absolute: Diarrhea associated with toxins, pseudomembranous colitis, respiratory depression (<12 beats/min) Acute asthma, bradycardia... View More

Mode of Action

Nalbuphine is a phenanthrene derivative opioid analgesic with mixed opioid agonist and antagonist activity. It inhibits the ascending pain pathways, alt... View More


May impair ability to drive or operate machinery. Emotionally unstable patients or patients with history of opiate abuse; closely monitor these patients... View More

Side Effect

>10% Sedation (36%) 1-10% Clamminess (9%),Nausea and vomiting (6%),Dizziness (5%),Xerostomia (4%),Headache (3%) <1% Asthma,Bradycardia,Burning,... View More

Pregnancy Category Note

Pregnancy category: B; D if used for prolonged periods or near term


Additive CNS depressant effects may occur with other CNS depressants e.g. alcohol, anaesthetics, anxiolytics, hypnotics, TCAs and antipsychotics.

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The information provided herein is accurate, updated and complete as per the best practices of the Company. Please note that this information should not... View More

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