Consuming alcohol while taking Rectocare may cause symptoms such as flushing, increased heart beat, nausea, thirst, chest pain and low blood pressure (Disulfiram reaction).
SAFE IF PRESCRIBED
Rectocare is generally considered safe to use during pregnancy. Animal studies have shown low or no adverse effects to the developing baby; however, there are limited human studies.
SAFE IF PRESCRIBED
Rectocare is probably safe to use during breastfeeding. Limited human data suggests that the drug does not represent any significant risk to the baby.
UNSAFE
Rectocare may decrease alertness, affect your vision or make you feel sleepy and dizzy. Do not drive if these symptoms occur.
SAFE IF PRESCRIBED
Rectocare is probably safe to use in patients with kidney disease. Limited data available suggests that dose adjustment of Rectocare may not be needed in these patients. Please consult your doctor.
CONSULT YOUR DOCTOR
There is limited information available on the use of Rectocare in patients with liver disease. Please consult your doctor.
Medicine Overview of Rectocare 0.40% Ointment
Introduction
Rectocare is used to treat and prevent heart-related chest pain (angina). Angina occurs when the heart muscle is not getting enough blood. This medicine works by relaxing and widening blood vessels so blood can flow more easily to the heart. It has a very short-lived effect.
Rectocare is given as an injection under the supervision of a doctor with careful blood pressure monitoring. This is given as a continuous infusion into a vein and should not be stopped abruptly. It should not be mixed with any other medication of any kind.
The most common side effect of Rectocare is a headache which may be severe. This can sometimes be helped by drinking plenty of fluids and avoiding alcohol. You may also experience lightheadedness, which could increase your risk of having a fall. There are other, rarer side effects, some of them serious. Ask your doctor and read the leaflet which comes with the medicine to make sure you are keeping safe.
Do not use Rectocare if you are taking medicines to treat high blood pressure in your lungs (pulmonary hypertension), or erectile dysfunction; or if you have anaemia or glaucoma (increased pressure inside the eye). Always tell your doctor what other health conditions you have and what other medicines you are taking. It is best not to drink alcohol with this medicine as it increases some of the side effects. If you are affected by dizziness, avoid driving. If you are pregnant, thinking about becoming pregnant, or breastfeeding, ask your doctor before taking this medicine.
Uses of Rectocare
Angina (heart-related chest pain)
Side effects of Rectocare
Common
Headache
How to use Rectocare
Your doctor or nurse will give you this medicine. Kindly do not self administer.
How Rectocare works
Rectocare is a nitrate. It works by relaxing the blood vessels which decreases the oxygen demand of the heart and reduces its workload, thereby preventing/treating attacks of angina (chest pain).
Quick Tips
It is given via a drip into a vein under the supervision of a doctor.
It may cause headaches which usually go away after a few days of continued treatment. Inform your doctor if it persists.
Rectocare may cause dizziness or sleepiness. Do not drive or do anything that requires concentration until you know how it affects you.
Do not consume alcohol while taking Rectocare as it may cause increased dizziness.
Stop taking medications (prescribed for erectile dysfunction) like sildenafil or tadalafil while on treatment with Rectocare as it may cause low blood pressure.
Brief Description
Indication
Chronic anal fissure
Administration
Gently insert the ointment into the anal canal using the finger. The finger with the ointment must be inserted to the first finger joint (approximately 1 cm) into the anus. Treatment may be continued until the pain goes away, or for up to a maximum 8 weeks.
Adult Dose
Rectal Anal fissure As 0.4% oint: Apply 1.5 mg 12 hrly up to 8 wk applied to the anal canal.
Contraindication
Do not use Glyceryl Trinitrate 0.4% ointment if the patients:
are allergic to glyceryl trinitrate or to similar medicines
suffer from low blood pressure
suffer from heart or blood vessel disorders
suffer from closed-angle glaucoma
suffer from migraine or recurrent headaches
suffer from increased intracranial pressure or high pressure within your skull
suffer from anaemia
are taking any of the following medicines: sildenafil citrate, tadalafil, vardenafil, medicines for angina or heart pain such as glyceryl trinitrate (GTN), isosorbide dinitrate, amyl or butyl nitrite, medicines for high blood pressure or depression (tricyclic anti-depressants), acetyl cysteine or alteplase
Mode of Action
Glyceryl trinitrate acts on the enzyme nitric oxide stimulating guanylate cyclase in the vascular smooth muscle cells resulting in the relaxation of smooth muscles. It reduces venous return (preload) and facilitates subendocardial blood flow with redistribution into ischaemic areas. It relieves coronary vasospasm and dilates arterioles reducing afterload. It is useful for relief and prevention of anginal attacks.
Precaution
Take special care with Glyceryl Trinitrate 0.4% ointment if patient has:
liver or kidney disease
to be given heparin
haemorrhoids (piles) and notice more bleeding than usual,
severe headaches when using ointment,
The ointment may lower blood pressure. Blood pressure is more likely to be lowered if drink alcohol whilst you are using ointment.
Ointment is not indicated for patients under the age of 18 years.
Side Effect
Headache is the most common side-effect when glyceryl trinitrate 0.4% ointment is used. Other side-effects include dizziness, faintness on standing, light-headedness, blurred vision and tiredness & nausea.
Interaction
Enhances bioavailability of dihydroergotamine. Glyceryl trinitrate infusion may prolong pancuronium-induced neuromuscular blockade. May reduce the efficacy of heparin, alteplase and noradrenaline when used together. Efficacy of buccal and sublingual preparations may be reduced by drugs that can cause dry mouth due to decreased dissolution. Aspirin and other NSAIDs may reduce the therapeutic response to glyceryl trinitrate.
Potentially Fatal: Orthostatic hypotension may be produced by combined use of calcium channel blockers, antihypertensives, phenothiazines and TCAs. Alcohol may cause severe hypotension and collapse.
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The information provided herein is accurate, updated and complete as per the best practices of the Company. Please note that this information should not be treated as a replacement for physical medical consultation or advice. We do not guarantee the accuracy and the completeness of the information so provided. The absence of any information and/or warning to any drug shall not be considered and assumed as an implied assurance of the Company. We do not take any responsibility for the consequences arising out of the aforementioned information and strongly recommend you for a physical consultation in case of any queries or doubts.