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Drug International Ltd.
Generic: Saxagliptin
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descriptionSafety Advices
It is unsafe to consume alcohol with Sixtin.
Sixtin is generally considered safe to use during pregnancy. Animal studies have shown low or no adverse effects to the developing baby; however, there ... View More
Sixtin is probably safe to use during breastfeeding. Limited human data suggests that the drug does not represent any significant risk to the baby.
Your ability to drive may be affected if your blood sugar is too low or too high. Do not drive if these symptoms occur.
Sixtin should be used with caution in patients with kidney disease. Dose adjustment of Sixtin may be needed. Please consult your doctor. Regular monitor... View More
Sixtin should be used with caution in patients with severe liver disease. Dose adjustment of Sixtin may be needed. Please consult your doctor. No dose a... View More
descriptionMedical Overview


Sixtin is a medicine used to treat type 2 diabetes mellitus. It is used together with a healthy diet and regular exercise to control blood sugar levels.... View More

Uses of Sixtin

  • Type 2 diabetes mellitus

Side effects of Sixtin

  • Headache
  • Nasopharyngitis (inflammation of the throat and nasal passages)
  • Urinary tract infection
  • Hypoglycaemia (low blood sugar level) in combination with insulin or sulphonylurea
  • Upper respiratory tract infection

How to use Sixtin

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Sixtin may be taken with o... View More

How Sixtin works

Sixtin is an antidiabetic medication. It works by increasing the release of insulin from the pancreas and decreasing the hormones that raise blood sugar... View More

What if you forget to take Sixtin?

If you miss a dose of Sixtin, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your re... View More

quick tipsQuick Tips
  • Sixtin should be taken at the same time every day since this helps you remember to take it.
  • Be careful while driving or operating machinery until you know how Sixtin affects you.
  • It may cause hypoglycemia (low blood sugar level) when used with other antidiabetic medicines, alcohol or if you delay or miss a meal.
  • Always carry some sugary food or fruit juice with you in case you experience hypoglycemia symptoms such as cold sweats, cool pale skin, tremor and anxie... View More
  • Inform your doctor if you notice joint pains or develop symptoms such as stomach pain, nausea and/or vomiting.
descriptionBrief Description


Type 2 diabetes


May be taken with or without food.

Adult Dose

Oral Type 2 diabetes mellitus Adult: 2.5 or 5 mg once daily. Combination therapy: May need to reduce dosage of sulfonylurea or other insulin secreta... View More

Child Dose

<18 years: Safety and efficacy not established

Renal Dose

Renal impairment CrCl >50 mL/min: No dose adjustment required CrCl <50 mL/min: Not to exceed 2.5 mg PO qDay ESRD requiring hemodialysis: Not to excee... View More


Documented hypersensitivity (eg, anaphylaxis, angioedema, exfoliative skin conditions)

Mode of Action

Dipeptidyl peptidase IV (DPP-4) inhibition that results in increased incretin hormones and enhanced glycemic control.


Renal impairment Decrease dose with strong CYP450 3A4/5 inhibitors Coadministration with thiazolidinediones (eg, rosiglitazone, pioglitazone) increase... View More

Side Effect

1-10% (selected) Urinary tract infection (7%),Headache (7%),Hypersensitivity-related events (<4%; eg, urticaria, facial edema),Peripheral edema (<4%; i... View More


Strong CYP3A4/5 inhibitors (eg ketoconazole, atazanavir, clarithromycin, indinavir, itraconazole, nefazodone, nelfinavir, ritonavir, saquinavir & telith... View More


The information provided herein is accurate, updated and complete as per the best practices of the Company. Please note that this information should not... View More

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