Introduction
Sumigran is a prescription medicine used in the treatment of migraine. It relieves the symptoms of migraine and prevents the attack from becoming worse. This medicine helps by narrowing the blood vessels, thereby relieving migraine headaches.
Sumigran may be taken with or without food. However, it is advised to take it at the same time each day as this helps to maintain a consistent level of medicine in the body. Do not skip any doses and finish the full course of treatment even if you feel better and if you have missed a dose, take it as soon as you remember. You should continue to take this medicine for as long as doctor advises and do not stop taking it suddenly.
Side effects associated with the use of this medicine include dizziness, weakness, drowsiness, peripheral neuropathy (tingling and numbness of feet and hands) and flushing (sense of warmth in the face, ears, neck and trunk). However, these are usually temporary and usually resolve on their own. Please consult your doctor if these do not subside or worry you.
It may also cause sleepiness in the beginning of your treatment, so do not drive, operate machinery, until you know how this medicine affects you. This medicine may cause changes in your mood and you may feel depressed, therefore, regular monitoring of behavior is important. Pregnant or breastfeeding mothers should consult their doctor before taking this medicine.
Inform your doctor if you are suffering from any heart problems, as the use of Sumigran is contraindicated in some heart diseases. Regular monitoring of blood pressure is required while taking this medicine. Consult your doctor and stop this medicine if you develop severe chest or stomach pain, bloody diarrhea, or significantly high blood pressure, after taking this medicine.
Side effects of Sumigran
Common
- Dizziness
- Weakness
- Flushing (sense of warmth in the face, ears, neck and trunk)
- Drowsiness
- Peripheral neuropathy (tingling and numbness of feet and hand)
How to use Sumigran
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Sumigran may be taken with or without food, but it is better to take it at a fixed time.
How Sumigran works
Migraine headaches are thought to result from the dilatation (swelling) of blood vessels in the head. Sumigran works by constricting (narrowing) the blood vessels in the head, stops transmission of pain signals to the brain, and blocks the release of chemicals that cause nausea and other migraine symptoms. This relieves the migraine attack.
Indication
Migraine, Cluster headache
Administration
May be taken with or without food.
Adult Dose
Oral
Migraine
Adult: >18 yr: 50-100 mg repeated at 2-hr intervals if migraine recurs. Max: 200 mg/24 hr.
Mild to moderate hepatic impairment: Max single dose: 50 mg.
Severe hepatic impairment: Contraindicated
Child Dose
<18 years: Safety and efficacy not established
Contraindication
Not to be used prophylactically and in patients with basilar or hemiplegic or ophthalmoplegic migraine. History of MI or stroke, severe hepatic impairment, ischaemic heart disease, uncontrolled hypertension, peripheral vascular disease, hypersensitivity to sulfonamides.
Mode of Action
Sumatriptan is a selective serotonin agonist that acts at 5-HT1 receptors. It causes vasoconstriction of cranial arteries and/or inhibition of neurogenic inflammatory processes in the CNS. A small but significant delay in gastric emptying also occurs.
Precaution
Conditions predisposing to seizures, presence of coronary risk factors, cardiac arrhythmias, renal or hepatic impairment, elderly, pregnancy, lactation.
Lactation: Excreted in breast milk at very low levels; minimize infant to potential exposure by avoiding breastfeeding for 8-12 hours after administration
Side Effect
>10%
Injection site reaction (<86%),Paresthesia (5-14%),Dizziness (12%),Warm/hot sensation (11%)
1-10%
Chest discomfort/pressure/tightness (2-5%),Jaw or neck tightness (1-5%),Diaphoresis (2%),Burning sensation (7%),Cold sensation (1%),Dysphagia,Sore throat (3%),Malaise (1%),Abdominal distress (1%)
Frequency Not Defined
Agitation,Cardiac arrhythmia: V-fib/V-tach (rare),Dysuria,Eye irritation,Flushing,MI and coronary artery vasospasm in patients with CAD risk factors (extremely rare),Nasal discomfort,Palpitations,Tingling,Weakness
Potentially Fatal: Cardiac arrhythmias, MI.
Interaction
Concurrent use increased risk of vasospastic reaction with ergotamine and related compounds.
Potentially Fatal: Increased risk of serotonin syndrome with concurrent use of SSRI, MAOIs or within 14 days of stopping MAOIs. Admin of ergotamine or related compounds within the previous 24 hr.