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Beximco Pharmaceuticals Ltd.
Generic: Simvastatin
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descriptionSafety Advices
It is unsafe to consume alcohol with Avastin.
Avastin is highly unsafe to use during pregnancy. Seek your doctor's advice as studies on pregnant women and animals have shown significant harmful effe... View More
Avastin is unsafe to use during breastfeeding. Data suggests that the drug may cause toxicity to the baby.
Avastin does not usually affect your ability to drive.
Avastin should be used with caution in patients with severe kidney disease. Dose adjustment of Avastin may be needed. Please consult your doctor.
Avastin should be used with caution in patients with liver disease. Dose adjustment of Avastin may be needed. Please consult your doctor. Use of Avastin... View More
descriptionMedical Overview


Avastin belongs to a group of medicines called statins. It is used to lower cholesterol and to reduce the risk of heart disease. Cholesterol is a fatty ... View More

Uses of Avastin

  • High cholesterol
  • Prevention of heart attack and stroke

Side effects of Avastin

  • Abdominal pain
  • Constipation
  • Headache
  • Upper respiratory tract infection

How to use Avastin

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Avastin may be taken with ... View More

How Avastin works

Avastin is a lipid-lowering medication (statin). It works by blocking an enzyme (HMG-CoA-reductase) that is required in the body to make cholesterol. It... View More

What if you forget to take Avastin?

If you miss a dose of Avastin, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your r... View More

quick tipsQuick Tips
  • It should be taken in the evening after dinner and before sleeping.
  • It should be taken in addition to regular exercise and low-fat diet to lower levels of fat in the blood.
  • Inform your doctor if you experience fatigue, muscle weakness or muscle pain.
  • Your doctor may check your liver function before starting the treatment and regularly thereafter. Inform your doctor if you notice signs of liver proble... View More
  • Inform your doctor if you have kidney disease, liver disease or diabetes before starting treatment with this medicine. If you are diabetic, monitor your... View More
  • Do not take Avastin if you are pregnant, planning a pregnancy or breastfeeding.
descriptionBrief Description


Hyperlipidaemias, stroke prevention


May be taken with or without food.

Adult Dose

Oral Hyperlipidaemias, Hypercholesterolemia Adult: Initially, 10-20 mg once daily. Patients w/ high CV risk or require a large reduction in choleste... View More

Child Dose

Child Heterozygous familial hypercholesterolaemia: 10-17 yr Initially, 10 mg once daily May increase at intervals of 4 wk to max 40 mg/day. All dos... View More

Renal Dose

Renal impairment: Mild to moderate: No dosage adjustment needed. Severe: Initially, 5 mg once daily w/ close monitoring.


Acute liver disease or unexplained persistent elevations of serum transaminases. Patients of Chinese descent should not take simvastatin 80 mg/day w/ li... View More

Mode of Action

Simvastatin, an antilipemic agent is a competitive inhibitor of HMG-CoA reductase, the enzyme that catalyses the early and rate-limiting step in cholest... View More


History of liver disease. Increased risk of rhabdomyolysis in severe infection, hypotension, major surgical trauma, uncontrolled seizures or severe meta... View More

Side Effect

1-10% CPK elevation (>3x ULN) (5%),Constipation (2%),Upper respiratory infection (9%),Flatulence (1-2%),Transaminases increased (>3x ULN) (1%),Headache... View More


May increase bleeding risk w/ anticoagulants. Reduced serum levels w/ bosentan, efavirenz and rifampicin. Increased risk of myopathy and rhabdomyolysis ... View More


The information provided herein is accurate, updated and complete as per the best practices of the Company. Please note that this information should not... View More

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