Introduction
Ucol 2 is used in the treatment of overactive bladder. It relieves urinary symptoms like frequent urination, urgent need to urinate and inability to control urination.
Ucol 2 is advised to take it in a dose and duration as per prescription. It can be taken with or without food, but take it at the same time regularly. Swallow the medicine as a whole without crushing or chewing it. You should not stop taking the medicine without consulting the doctor as it may lead to the worsening of your symptoms. The course of the treatment should be completed for better efficacy of the medicine.
Some common side effects of this medicine are dry mouth, constipation, diarrhea, headache, etc. To cope up with the side effects, you must drink plenty of water. It may also make you feel dizzy or sleepy or experience blurry vision, so it advised not to drive or do anything requiring concentration until you know how it affects you. Consumption of alcohol must be avoided as it can aggravate the side effects. If any of the side effects bother you or persist, consult the doctor without delay.
Before receiving the treatment, inform your doctor if you are on any medication for any other health condition. If you are pregnant or breastfeeding, tell your doctor prior to the treatment. Patients with liver or kidney disease must be cautious while receiving the prescription and they must receive regular follow-ups as per the doctor's advice.
Uses of Ucol 2
- Overactive bladder (OAB) symptoms
Side effects of Ucol 2
Common
- Dryness in mouth
- Constipation
- Headache
- Dizziness
- Sleepiness
- Blurred vision
- Dry skin
How to use Ucol 2
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Ucol 2 may be taken with or without food, but it is better to take it at a fixed time.
How Ucol 2 works
Ucol 2 is an antimuscarinic. It works by relaxing muscles of the urinary bladder and prevents frequent, urgent or uncontrolled urination.
What if you forget to take Ucol 2?
If you miss a dose of Ucol 2, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
Indication
Overactive bladder
Adult Dose
Oral
Overactive Bladder, Urge Incontinence
Immediate release: 2 mg PO q12hr. Reduce to 1 mg bid if needed to reduce side effects.
Extended release: 2-4 mg PO once daily
Hepatic impairment
Mild to moderate (Child-Pugh class A or B): Not to exceed 1 mg PO q12hr (immediate release) or 2 mg PO once daily (extended release)
Severe (Child-Pugh class C): Not recommended
Child Dose
Child < 18 years: Not recommended
Renal Dose
Renal impairment
CrCl 10-30 mL/min: Not to exceed 1 mg PO q12hr (immediate release) or 2 mg PO once daily (extended release)
CrCl <10 mL/min: Not recommended
Contraindication
Severe ulcerative colitis, toxic megacolon, urinary retention, gastric retention, myasthenia gravis, uncontrolled narrow-angle glaucoma, pregnancy.
Mode of Action
Tolterodine is a competitive muscarinic receptor antagonist with actions similar to atropine. It is used in the management of urge urinary incontinence, urgency and frequency.
Precaution
Bladder flow obstruction, GI obstructive disorders, renal or hepatic impairment, autonomic neuropathy, hiatus hernia, risk of decreased GI motility, patients at risk of QT interval prolongation (e.g. electrolyte disturbances, bradycardia, pre-exisiting cardiac disorder).
Lactation: Unknown whether drug is distributed in breast milk; do not nurse
Side Effect
>10%
Dry mouth (40%)
1-10%
Blurred vision,Constipation,Dizziness,Drowsiness,Dyspepsia,Headache,Xerophthalmia
Interaction
Increased risk of overdosage with potent CYP3A4 inhibitors e.g. macrolide antibiotics (erythromycin and clarithromycin), azole antifungals (e.g. ketoconazole and itraconazole), protease inhibitors, ciclosporin or vinblastine. Increased risk of torsade de pointes with drugs that prolong the QT interval (e.g. class Ia and class III antiarrhythmics). Increased risk of 'cholinergic neurogenic hypersensitivity' with centrally acting anticholinesterases (e.g. donepezil, rivastigmine). Increased risk of antimuscarinic side effects with antimuscarinic drugs.