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Zidovudine50mg/5ml

Syrup
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EDCL
Generic: Zidovudine
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descriptionSafety Advices
AlcoholAlcohol
CAUTION
Caution is advised when consuming alcohol with Zidovudine. Please consult your doctor.
PregnancyPregnancy
CONSULT YOUR DOCTOR
Zidovudine may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the develop... View More
BreastfeedingBreastfeeding
SAFE IF PRESCRIBED
Zidovudine is probably safe to use during breastfeeding. Limited human data suggests that the drug does not represent any significant risk to the baby.
DrivingDriving
UNSAFE
Zidovudine may decrease alertness, affect your vision or make you feel sleepy and dizzy. Do not drive if these symptoms occur.
KidneyKidney
CAUTION
Zidovudine should be used with caution in patients with severe kidney disease. Dose adjustment of Zidovudine may be needed. Please consult your doctor.
LiverLiver
CAUTION
Zidovudine should be used with caution in patients with liver disease. Dose adjustment of Zidovudine may be needed. Please consult your doctor. Use of Z... View More
descriptionMedical Overview

Introduction

Zidovudine belongs to a group of medicines called antiretrovirals. It is used to treat HIV (human immunodeficiency virus), the virus that can cause AIDS... View More

Uses of Zidovudine

  • HIV infection

Side effects of Zidovudine

Common
  • Fatigue
  • Headache
  • Decreased appetite
  • Nausea
  • Vomiting
  • Muscle pain

How to use Zidovudine

Take this medicine in the dose and duration as advised by your doctor. Do not chew, crush or break it. Zidovudine may be taken with or without food, but... View More

How Zidovudine works

Zidovudine is an antiviral medication. It prevents the multiplication of virus in human cells. This stops the virus from producing new viruses and clear... View More

What if you forget to take Zidovudine?

If you miss a dose of Zidovudine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to you... View More

quick tipsQuick Tips
  • In combination with other medicines, it is used for the treatment of HIV infections.
  • Take it with food, as this increases the absorption of the medicine into the body.
  • Zidovudine may cause dizziness or sleepiness. Do not drive or do anything requiring concentration until you know how it affects you.
  • You may still develop infections or other illnesses associated with viral infection while taking this medication.
  • You can also pass on HIV or HBV to others. Don't share needles or personal items that can have blood or body fluids on them.
  • During treatment and for at least six months after stopping this medicine, regular blood tests are needed to monitor your liver function, level of hepat... View More
descriptionBrief Description

Indication

Cancer therapy-induced hyperuricaemia, HIV infection

Administration

May be taken with or without food. IV Preparation Dilute to not to exceed 4 mg/mL w/ D5W IV Administration Infuse over 1 hr

Adult Dose

HIV Infection 300 mg PO q12hr OR 200 mg PO q8hr (600 mg/day) IV: 1 mg/kg/dose 5-6x/day Maternal Dosing to Prevent Fetal HIV Transmission FDA-app... View More

Child Dose

HIV Infection, Treatment 4 weeks-18 years 240 mg/m² PO q12hr or 160 mg/m² PO q8hr, OR use mg/kg dosing 4 to <9 kg: 12 mg/kg PO q12hr or 8 mg/kg PO ... View More

Renal Dose

Renal Impairment CrCl < 15 mL/min (maintained on hemodialysis or peritoneal dialysis): 100 mg PO or 1 mg/kg IV q6-8 hr; alternatively 100 mg PO qDay or... View More

Contraindication

Hypersensitivity; abnormally low neutrophil counts (<0.75 x 109/L) or Hb levels (<7.5 g/dL or 4.65 mmol/L); newborn infants w/ hyperbilirubinaemia requi... View More

Mode of Action

Zidovudine is a thymidine analogue. It is phosphorylated in the body to its active form zidovudine triphosphate which interferes in DNA synthesis of ret... View More

Precaution

Severe renal and hepatic impairment. Childn. Pregnancy. Monitoring Parameters Monitor viral load, CD4 count; CBC w/ differential, LFT, lipid, glucose. O... View More

Side Effect

>10% Anemia (23% in children),Anorexia (11%),Diarrhea (17%),Fever (16%),Granulocytopenia (39% in children),Headache, severe (42%),Leukopenia (39%),Naus... View More

Interaction

Decreased zidovudine concentration with tipranavir. Increased risk of peripheral neuropathy with bortezomib. Increased haematological toxicity with IV p... View More

descriptionDisclaimer

The information provided herein is accurate, updated and complete as per the best practices of the Company. Please note that this information should not... View More