Zidovudine50mg/5ml
Syrup
EDCL
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| Alcohol | CAUTION Caution is advised when consuming alcohol with Zidovudine. Please consult your doctor. |
| Pregnancy | CONSULT YOUR DOCTOR Zidovudine may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the develop... View More |
| Breastfeeding | SAFE IF PRESCRIBED Zidovudine is probably safe to use during breastfeeding. Limited human data suggests that the drug does not represent any significant risk to the baby. |
| Driving | UNSAFE Zidovudine may decrease alertness, affect your vision or make you feel sleepy and dizzy. Do not drive if these symptoms occur. |
| Kidney | CAUTION Zidovudine should be used with caution in patients with severe kidney disease. Dose adjustment of Zidovudine may be needed. Please consult your doctor. |
| Liver | CAUTION Zidovudine should be used with caution in patients with liver disease. Dose adjustment of Zidovudine may be needed. Please consult your doctor.
Use of Z... View More |
Introduction
Zidovudine belongs to a group of medicines called antiretrovirals. It is used to treat HIV (human immunodeficiency virus), the virus that can cause AIDS... View More
Uses of Zidovudine
- HIV infection
Side effects of Zidovudine
- Fatigue
- Headache
- Decreased appetite
- Nausea
- Vomiting
- Muscle pain
How to use Zidovudine
Take this medicine in the dose and duration as advised by your doctor. Do not chew, crush or break it. Zidovudine may be taken with or without food, but... View More
How Zidovudine works
Zidovudine is an antiviral medication. It prevents the multiplication of virus in human cells. This stops the virus from producing new viruses and clear... View More
What if you forget to take Zidovudine?
If you miss a dose of Zidovudine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to you... View More
- In combination with other medicines, it is used for the treatment of HIV infections.
- Take it with food, as this increases the absorption of the medicine into the body.
- Zidovudine may cause dizziness or sleepiness. Do not drive or do anything requiring concentration until you know how it affects you.
- You may still develop infections or other illnesses associated with viral infection while taking this medication.
- You can also pass on HIV or HBV to others. Don't share needles or personal items that can have blood or body fluids on them.
- During treatment and for at least six months after stopping this medicine, regular blood tests are needed to monitor your liver function, level of hepat... View More
Indication
Cancer therapy-induced hyperuricaemia, HIV infection
Administration
May be taken with or without food. IV Preparation Dilute to not to exceed 4 mg/mL w/ D5W IV Administration Infuse over 1 hr
Adult Dose
HIV Infection 300 mg PO q12hr OR 200 mg PO q8hr (600 mg/day) IV: 1 mg/kg/dose 5-6x/day Maternal Dosing to Prevent Fetal HIV Transmission FDA-app... View More
Child Dose
HIV Infection, Treatment 4 weeks-18 years 240 mg/m² PO q12hr or 160 mg/m² PO q8hr, OR use mg/kg dosing 4 to <9 kg: 12 mg/kg PO q12hr or 8 mg/kg PO ... View More
Renal Dose
Renal Impairment CrCl < 15 mL/min (maintained on hemodialysis or peritoneal dialysis): 100 mg PO or 1 mg/kg IV q6-8 hr; alternatively 100 mg PO qDay or... View More
Contraindication
Hypersensitivity; abnormally low neutrophil counts (<0.75 x 109/L) or Hb levels (<7.5 g/dL or 4.65 mmol/L); newborn infants w/ hyperbilirubinaemia requi... View More
Mode of Action
Zidovudine is a thymidine analogue. It is phosphorylated in the body to its active form zidovudine triphosphate which interferes in DNA synthesis of ret... View More
Precaution
Severe renal and hepatic impairment. Childn. Pregnancy. Monitoring Parameters Monitor viral load, CD4 count; CBC w/ differential, LFT, lipid, glucose. O... View More
Side Effect
>10% Anemia (23% in children),Anorexia (11%),Diarrhea (17%),Fever (16%),Granulocytopenia (39% in children),Headache, severe (42%),Leukopenia (39%),Naus... View More
Interaction
Decreased zidovudine concentration with tipranavir. Increased risk of peripheral neuropathy with bortezomib. Increased haematological toxicity with IV p... View More
The information provided herein is accurate, updated and complete as per the best practices of the Company. Please note that this information should not... View More