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Zulfidin 500500mg

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Unimed Unihealth Pharmaceuticals Ltd.
Generic: Sulfasalazine
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descriptionSafety Advices
It is unsafe to consume alcohol with Zulfidin 500.
Zulfidin 500 is generally considered safe to use during pregnancy. Animal studies have shown low or no adverse effects to the developing baby; however, ... View More
Zulfidin 500 is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.
Zulfidin 500 does not usually affect your ability to drive.
Zulfidin 500 should be used with caution in patients with kidney disease. Dose adjustment of Zulfidin 500 may be needed. Please consult your doctor. Reg... View More
Zulfidin 500 is probably unsafe to use in patients with liver disease and should be avoided. Please consult your doctor.
descriptionMedical Overview


Zulfidin 500 is a medicine used to treat various inflammatory conditions of the joints (rheumatoid arthritis, psoriatic arthritis, ankylosing spondyliti... View More

Uses of Zulfidin 500

  • Rheumatoid arthritis
  • Ulcerative colitis
  • Crohn’s disease
  • Ankylosing spondylitis

Side effects of Zulfidin 500

  • Diarrhea
  • Gastrointestinal discomfort
  • Headache
  • Loss of appetite
  • Nausea
  • Oligospermia (low sperm count)
  • Vomiting
  • Weight loss

How to use Zulfidin 500

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Zulfidin 500 is to be take... View More

How Zulfidin 500 works

Zulfidin 500 is a Disease Modifying Anti-Rheumatoid Drug (DMARD). It works by suppressing the overactivity of the immune system in autoimmune diseases a... View More

What if you forget to take Zulfidin 500?

If you miss a dose of Zulfidin 500, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to y... View More

quick tipsQuick Tips
  • Take it with food to avoid an upset stomach.
  • It may take 6-8 weeks for Sazo 500 Tablet DR to work. Keep taking it as prescribed.
  • Drink plenty of fluids while taking Sazo 500 Tablet DR in order to avoid kidney problems such as kidney stones.
  • It may cause a deficiency of folic acid. Take the supplements as suggested by the doctor.
  • Do not take Sazo 500 Tablet DR if you are allergic to sulfa drugs or aspirin.
  • It may discolour your skin, urine, saliva and tears an orange/yellow colour. This is normal and not harmful.
  • Regular blood tests to monitor your liver function, kidney function, and the levels of your blood components are required while taking this medicine.
  • Do not stop taking the medication suddenly without talking to your doctor.
descriptionBrief Description


Inflammatory bowel disease, Rheumatoid arthritis


Should be taken with food. Take after meals. Ensure adequate fluid intake.

Adult Dose

Oral Inflammatory bowel disease Adult: Initially, 1-2 g 4 times daily until remission occurs. Maintenance: 2 g/day in divided doses. Rheumatoid art... View More

Child Dose

Oral Inflammatory bowel disease Child: >2 yr: 40-60 mg/kg/day in divided doses. Maintenance: 20-30 mg/kg/day in divided doses. Rheumatoid arthritis... View More

Renal Dose

Renal impairment: CrCl (ml/min) Dosage Recommendation 10-30ml/min Admin twice daily. <10ml/min Admin once daily.


Hypersensitivity to sulphonamides or salicylates, porphyria, <2 yr of age, intestinal or urinary obstruction, blood dycrasias, history of leucopenia wit... View More

Mode of Action

Actual mechanism not determined. Sulphasalazine may have direct anti-inflammatory action in the colon. It also systemically interferes with secretion by... View More


Hepatic/renal impairment, G6PD deficiency, allergic bronchial asthma, lactation. Lactation: Excreted into human breast milk; caution with breastfeedi... View More

Side Effect

>10% Anorexia (~33%),Headache (~33%),Nausea (~33%),Vomiting (~33%),Gastric distress (~33%),Apparently reversible oligospermia (~33%) <1% Skin rash,... View More

Pregnancy Category Note

Pregnancy category: B; D if used for prolonged periods or near term; increased potential for kernicterus in the newborn


Plasma levels reduced by rifampicin and ethambutol. Interferes with absorption of folic acid. Additive leucopaenia with gold therapy for rheumatoid arth... View More

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The information provided herein is accurate, updated and complete as per the best practices of the Company. Please note that this information should not... View More