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Pulmoten 62.562.5mg

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Unimed Unihealth Pharmaceuticals Ltd.
Generic: Bosentan
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descriptionSafety Advices
Pulmoten 62.5 may cause excessive drowsiness with alcohol.
Pulmoten 62.5 is highly unsafe to use during pregnancy. Seek your doctor's advice as studies on pregnant women and animals have shown significant harmfu... View More
Pulmoten 62.5 is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.
Pulmoten 62.5 may cause side effects which could affect your ability to drive. As Pulmoten 62.5 can induce hypotension (decrease of your blood pressure)... View More
Pulmoten 62.5 is safe to use in patients with kidney disease. No dose adjustment of Pulmoten 62.5 is recommended.
Pulmoten 62.5 should be used with caution in patients with liver disease. Dose adjustment of Pulmoten 62.5 may be needed. Please consult your doctor. Us... View More
descriptionMedical Overview


Pulmoten 62.5 is a prescription medicine used to treat pulmonary arterial hypertension (high pressure in the blood vessels that carry blood from the hea... View More

Uses of Pulmoten 62.5

  • Pulmonary arterial hypertension (PAH)

Side effects of Pulmoten 62.5

  • Headache
  • Ankle swelling
  • Edema (swelling)
  • Diarrhea
  • Anemia (low number of red blood cells)
  • Respiratory tract infection

How to use Pulmoten 62.5

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Pulmoten 62.5 may be taken... View More

How Pulmoten 62.5 works

Pulmoten 62.5 is an endothelin receptor blocker. It blocks the action of endothelin (a natural substance) that causes blood vessels to narrow (constrict... View More

What if you forget to take Pulmoten 62.5?

If you miss a dose of Pulmoten 62.5, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to ... View More

quick tipsQuick Tips
  • Your doctor has prescribed Pulmoten 62.5 to treat high pressure in the blood vessels that carry blood from the heart to the lungs (the pulmonary arterie... View More
  • It helps improve your quality of life, exercising ability, and delay disease progression.
  • Notify your doctor if you are pregnant or planning to conceive or breastfeeding.
  • Your doctor may ask you to get routine blood tests done to check for anemia and to assess the functioning of your liver.
  • Do not drive or do anything requiring concentration until you know how Pulmoten 62.5 affects you.
  • Females with reproductive potential should use a reliable form of birth control while using and 1 month after stopping Pulmoten 62.5 as it is toxic to a... View More
  • Inform your doctor if you notice weight gain, swelling of your arms and legs, or difficulty breathing.
  • Inform your doctor if you notice yellowing of skin/eye, dark urine, or stomach pain.
descriptionBrief Description


Pulmonary Arterial Hypertension (PAH)


Bosentan should be administered in the morning and evening with or without food.

Adult Dose

Oral Pulmonary hypertension Adult: >12 yr <40 kg: Initial and maintenance dose is 62.5 mg bid; >40 kg: Initially, 62.5 mg bid for 4 wk, then increased... View More

Renal Dose

Renal impairment: No dosage adjustment needed in renal impairment or dialysis patients.


Patients with WHO Class II symptoms showed reduction in the rate of clinical deterioration and a trend for improvement in walk distance. Physicians shou... View More

Mode of Action

Competitive antagonist of endothelin-1; blocks endothelin receptors on vascular endothelium and smooth muscle resulting in inhibition of vasoconstrictio... View More


Hepatotoxicity and teratogenicity. Elevations of AST or ALT associated with Bosentan are dose-dependent, occur both early and late in treatment, usually... View More

Side Effect

>10% Hgb decreased; >1 g/dL (57%),Inhibition of spermatogenesis (25%),Headache (16-22%),Nasopharyngitis (11%),Transaminses increased (12%),Respiratory ... View More

Pregnancy Category Note

Pregnancy Based on animal data, bosentan may cause fetal harm, including birth defects and fetal death, when administered to a pregnant female and is c... View More


Increased bosentan levels w/ CYP3A4 inhibitors (e.g. ketoconazole, ritonavir, diltiazem), CYP2C9 inhibitors (e.g. amiodarone, fluconazole), tacrolimus. ... View More


The information provided herein is accurate, updated and complete as per the best practices of the Company. Please note that this information should not... View More

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