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Paxel 100100mg/vial

Injection
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Healthcare Pharmaceuticals Ltd.
Generic: Paclitaxel
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descriptionSafety Advices
AlcoholAlcohol
UNSAFE
It is unsafe to consume alcohol with Paxel 100.
PregnancyPregnancy
CONSULT YOUR DOCTOR
Paxel 100 is unsafe to use during pregnancy as there is definite evidence of risk to the developing baby. However, the doctor may rarely prescribe it in... View More
BreastfeedingBreastfeeding
UNSAFE
Paxel 100 is unsafe to use during breastfeeding. Data suggests that the drug may cause toxicity to the baby.
DrivingDriving
UNSAFE
Paxel 100 may cause side effects which could affect your ability to drive. As there is no reason why you cannot continue driving between courses of Paxe... View More
KidneyKidney
SAFE IF PRESCRIBED
Paxel 100 is safe to use in patients with kidney disease. No dose adjustment of Paxel 100 is recommended. However, talk to your doctor if you have any u... View More
LiverLiver
CAUTION
Paxel 100 should be used with caution in patients with liver disease. Dose adjustment of Paxel 100 may be needed. Please consult your doctor. Use of Pax... View More
descriptionMedical Overview

Introduction

Paxel 100 is an anti-cancer medication used for the treatment of breast cancer, pancreatic cancer and non-small cell lung cancer. It is given as an inj... View More

Uses of Paxel 100

  • Breast cancer
  • Non-small cell lung cancer
  • Pancreatic cancer

Side effects of Paxel 100

Common
  • Nausea
  • Vomiting
  • Weakness
  • Low blood platelets
  • Rash
  • Upper respiratory tract infection
  • Urinary tract infection
  • Bleeding
  • Anemia (low number of red blood cells)
  • Flushing (sense of warmth in the face, ears, neck and trunk)
  • Hair loss
  • Decreased blood pressure
  • Peripheral neuropathy (tingling and numbness of feet and hand)
  • Diarrhea
  • Decreased white blood cell count (neutrophils)

How to use Paxel 100

Your doctor or nurse will give you this medicine. Kindly do not self administer.

How Paxel 100 works

Paxel 100 is an anticancer medication. It works by interfering with the microtubule structures which help the cancer cells to divide and multiply. This ... View More

quick tipsQuick Tips
  • Paxel 100 is an anti-cancer medication used for the treatment of breast cancer, pancreatic cancer, and non-small cell lung cancer.
  • It is given as an intravenous (IV) injection into your vein, usually over 1 hour and every three weeks.
  • Do not take Paxel 100 if you are pregnant or breastfeeding. Use reliable methods of contraception to prevent pregnancy while taking this medicine.
  • Your doctor may get regular blood tests done to monitor your blood cells and liver function during treatment with this medicine.
  • Inform your doctor if you notice unexplained bruising or bleeding, sore throat, mouth ulcers, high temperature (fever) or other signs of infection.
  • Talk to your doctor if you have sudden weight gain or if you have swelling in your arms and legs that doesn't go away.
descriptionBrief Description

Indication

Ovarian carcinoma, Breast cancer, Lung cancer, Kaposi's sarcoma

Administration

Reconstitution: Paclitaxel must be diluted before infusion. It can be diluted in 0.9% sodium chloride inj, 5% dextrose inj, 5% dextrose and 0.9% sodium ... View More

Adult Dose

Intravenous Ovarian carcinoma Adult: Primary treatment (in combination with cisplatin or carboplatin): 135 mg/m2 infused over 24 hr followed by cispla... View More

Child Dose

Safety and efficacy not established

Contraindication

History of hypersensitivity (especially macrogol glycerol ricinolate). Patients with baseline neutropenia of <1500 cells/mm3 (<1000 cells/mm3 for kaposi... View More

Mode of Action

Paclitaxel promotes microtubule formation by enhancing the action of tubulin dimers, stabilising existing microtubules and preventing their disassembly,... View More

Precaution

Bone marrow suppression during therapy. Monitor cardiac function if conduction abnormalities result. Premedicaton (with corticosteroid, antihistamine an... View More

Side Effect

>10% Neutropenia (78-100%),Alopecia (55-96%),Anemia (47-96%),Arthralgia/myalgia (93%),Diarrhea (90%),Leukopenia (90%),Nausea/vomiting (9-88%),Opportuni... View More

Interaction

Myelosuppression was more profound when given after cisplatin than with the alternate sequence (e.g., paclitaxel before cisplatin). CYP2C8 inducers e.g.... View More

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descriptionDisclaimer

The information provided herein is accurate, updated and complete as per the best practices of the Company. Please note that this information should not... View More