Introduction
Lucent is the active form of Vitamin D. It increases the levels of Vitamin D in your blood which in turn raises calcium levels in the blood by helping in absorption of more calcium from your intestine. Thus, it is used in the treatment of calcium deficiency and postmenopausal osteoporosis.
Lucent is given in women after menopause to strengthen weak bones. It helps in reducing the bone damage. It is administered as an injection. It is advised not to self administer the injection, it should be done by a healthcare professional. In case of injection site reactions such as pain, swelling or redness, kindly consult your doctor.
Do not take any other form of Vitamin D along with this medicine without consultation of your doctor. Calcium supplements along with Vitamin D3 should only be taken with doctor's advice. Drink plenty of fluids such as water to avoid feeling dehydrated. Avoid using antacids as it can cause difficulty for the medicine to absorb.
Inform your doctor if you are pregnant. However, it is safe to use in breastfeeding mothers and liver disease patients. In case of kidney disease patients, dose adjustment is required. Caution is advised when consuming alcohol with Lucent.
Side effects of Lucent
Common
- Injection site reactions (pain, swelling, redness)
How to use Lucent
Your doctor or nurse will give you this medicine. Kindly do not self administer.
How Lucent works
Lucent is the active form of Vitamin D. It raises Vitamin D levels in your blood. This in turn raises calcium levels in your blood by helping you absorb more calcium from your intestine.
Indication
Osteoporosis, Hypoparathyroidism, Hypocalcaemia, Osteomalacia rickets, Renal osteodystrophy, Chronic kidney dialysis.
Administration
May be taken with or without food. May be taken w/ meals to reduce GI discomfort.
Adult Dose
Adult: Capsule: The optimal daily dose of Calcitriol must be carefully determined for each patient on the basis of the serum calcium level.
Calcitriol can be administered orally either 0.25 mcg or 0.50 mcg.
Postmenopausal osteoporosis
The recommended dosage is 0.25 mcg twice daily or 0.50 mcg once daily. Serum creatinine levels should be determined at 4 weeks, 3 and 6 months and 6 monthly intervals thereafter.
Renal osteodystrophy (Dialysis patients)
The recommended initial dose of Calcitriol is 0.25 mcg/day. Patients with normal or only slightly reduced serum calcium levels may respond to Calcitriol doses of 0.25 mcg every other day. Most patients undergoing hemodialysis respond to doses between 0.5 and 1 mcg/day.
Hypoparathyroidism & Rickets
The recommended initial dosage of Calcitriol is 0.25 mcg/day given in the morning. If a satisfactory response is not observed, the dose may be increased at 2 to 4 week intervals.
Predialysis patients:
The recommended initial dosage of Calcitriol is 0.25 mcg/day in adults. This dosage may be increased if necessary to 0.5 mcg/day.
Injection
The recommended intravenous initial dose of Calcitriol injection, depending on the severity of the hypocalcemia and/or secondary hyperparathyroidism, is 1 mcg (0.02 mcg/kg) to 2 mcg administered three times weekly, approximately every other day.
Doses as small as 0.5 mcg and as large as 4 mcg three times weekly have been used as an initial dose.
If a satisfactory response is not observed, the dose may be increased by 0.5 to 1 mcg at two to four week intervals.
Child Dose
Chronic Renal Dialysis Associated Hypocalcemia
0.25-2 mcg/day PO qDay
Hypoparathyroidism/Pseudohypoparathyroidism
<1 year: 0.04-0.08 mcg/kg PO qDay
1-5 years: 0.25-0.75 mcg PO qDay
>6 years: 0.5-2 mcg PO qDay
Familial Hypophosphatemia
Initial: 0.015-0.02 mcg/kg PO qDay
Maintenance: 0.03-0.06 mcg/kg PO qDay
No more than 2 mcg PO qDay
Secondary Hyperparathyroidism in Moderate to Severe Kidney Disease
<3 years: 0.01-0.015 mcg/kg/day
>3 years: 0.25 mcg/day PO; may increase to 0.5 mcg/day
Hypocalcemia in Premature Infants
1 mcg qDay PO for 5 days
Contraindication
Hypercalcaemia; evidence of vitamin D toxicity. Pregnancy (dose exceeding RDA). Lactation.
Mode of Action
Calcitriol promotes calcium absorption in the intestines and retention at the kidneys thus increasing serum calcium levels. It also increases renal tubule phosphate resorption consequently decreasing serum phosphatase levels, PTH levels and bone resorption..
Precaution
Idiopathic hypercalcaemia. Pediatric doses must be individualised and monitored under close medical supervision. Coronary disease, renal function impairment and arteriosclerosis, especially in the elderly. Hypoparathyroidism.
Excessive dosage of Calcitriol induces hypercalcemia and in some instances hypercalciuria; therefore, early in treatment during dosage adjustment, serum calcium should be determined twice weekly.
Patients with normal renal function who are taking Calcitriol should avoid dehydration. Adequate fluid intake should be maintained.
Lactation: Enters breast milk; not recommended
Side Effect
Abdominal pain,Apathy,BUN and creatinine increased,Cardiac arrhythmia,Constipation,Dry mouth,Dehydration,Growth suppression,Headache,Hyperthermia,Hypercalcemia,Hypercholesteremia,Hypermagnesemia,Hyperphosphatemia,Hypertension,Libido decreased,Metallic taste,Muscle or bone pain,Nocturia,Pruritus,Psychosis,Somnolence,Weakness
Pregnancy Category Note
Pregnancy category: C
Lactation: Enters breast milk; not recommended
Interaction
Hypermagnesaemia may develop in patients on chronic renal dialysis. Hypercalcaemia in patients on digitalis may precipitate cardiac arrhythmias. Intestinal absorption of calcitriol may be reduced by cholestyramine and colestipol. Phenytoin, barbiturates may decrease the T1/2 of calcitriol. May develop hypercalcaemia with thiazide diuretics.