Meslamin 400400mg

Indication

For the treatment of mildly to moderately active ulcerative colitis: The usual dosage in adults is two 400 mg tablets to be taken three times a day for ... View More

Administration

Do not give with lactulose or other drugs which lower pH for they prevent release of mesalazine. May decrease digoxin absorption.

Adult Dose

Mild to moderate impaired renal or hepatic function (test serum creatinine before treatment, every 3 mth for 1st yr, every 6 mth for next 4 yr, then ann... View More

Renal Dose

Anti-inflammatory agent; mesalamine (5-aminosalicylic acid) is the active component of sulfasalazine, but specific MOA is unknown; probably inhibits pro... View More

Contraindication

Ulcerative colitis: Dose is dependent on preparation and brand used. Tablets: 5-15 yr: Acute attack: 15-20 mg/kg (max: 1 g) tid; maintenance of remissio... View More

Mode of Action

May take with or without food.

Precaution

Ulcerative colitis, Ulcerative proctitis, Crohn's Disease.

Side Effect

Renal impairment: CrCl (ml/min) <20 Avoid.

Pregnancy Category Note

Abdominal pain (4-8%), GI discomfort (4-8%),Headache (7%),Flatulence (1-6%),Nausea (1-6%),Fatigue (3%),Asthenia (3%),Malaise (3%),Weakness (3%),Fever (3... View More

Interaction

Hypersensitivity to salicylates, aminosalicylates, or any component of the product.- Severe renal impairment (GFR less than 30 mL per minute).- Severe l... View More