Pegin180mcg/vial

Indication

Chronic hepatitis C, Chronic hepatitis B

Administration

Administer by SC injection once weekly in abdomen or thigh

Adult Dose

Subcutaneous Chronic hepatitis C Adult: 180 mcg SC once weekly for 48 weeks Treatment duration Monotherapy: 48 weeks Dual therapy with Ribavirin... View More

Child Dose

Chronic Hepatitis C Indicated in combination with ribavirin for treatment of chronic hepatitis C of children aged >5 yr with CHC and compensated liver ... View More

Renal Dose

Renal impairment CrCl 30-50 mL/min: 180 mcg once weekly CrCl <30 mL/min (including patients on hemodialysis): 135 mcg once weekly If severe adverse r... View More

Contraindication

Hypersensitivity to any component of the product. Autoimmune hepatitis; decompensated liver disease in cirrhotic patients (Child-Pugh score >6); decompe... View More

Mode of Action

Peginterferon alfa-2a are interferon proteins bound to polyethylene glycol (PEG) molecules resulting in higher and more prolonged serum interferon conce... View More

Precaution

Neuropsychiatric disorders, discontinue treatment with worsening or persistently severe signs/symptoms; myelosuppresion; anemia (spherocytosis, history ... View More

Side Effect

>10% Fatigue (24% to 67% ),Headache (27% to 54% ),Fever (24% to 54% ),Myalgia (26% to 51% ),Influenza-like illness (25% to 47% ),Rigor (25% to 47% ),Ne... View More

Pregnancy Category Note

Pregnancy Category: C (monotherapy); X (with ribavirin)

Interaction

Increased risk of haemolytic anemia, birth defects and/or foetal mortality, genotoxicity, mutagenicity, and may possibly be carcinogenic with ribavirin;... View More