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Lok 50 Plus12.5mg+50mg

Tablet
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Globe Pharmaceuticals Ltd.
Generic: Hydrochlorothiazide + Losartan Potassium
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descriptionSafety Advices
AlcoholAlcohol
UNSAFE
It is unsafe to consume alcohol with Lok 50 Plus.
PregnancyPregnancy
CONSULT YOUR DOCTOR
Lok 50 Plus is unsafe to use during pregnancy as there is definite evidence of risk to the developing baby. However, the doctor may rarely prescribe it ... View More
BreastfeedingBreastfeeding
SAFE IF PRESCRIBED
Lok 50 Plus is probably safe to use during breastfeeding. Limited human data suggests that the drug does not represent any significant risk to the baby.... View More
DrivingDriving
UNSAFE
Lok 50 Plus may decrease alertness, affect your vision or make you feel sleepy and dizzy. Do not drive if these symptoms occur.
KidneyKidney
CAUTION
Lok 50 Plus should be used with caution in patients with severe kidney disease. Dose adjustment of Lok 50 Plus may be needed. Please consult your doctor... View More
LiverLiver
CAUTION
Lok 50 Plus should be used with caution in patients with liver disease. Dose adjustment of Lok 50 Plus may be needed. Please consult your doctor.
descriptionMedical Overview

Introduction

Lok 50 Plus is a combination of two medicines. It helps to control high blood pressure in different ways. If high blood pressure is not treated it can l... View More

Uses of Lok 50 Plus

  • Hypertension (high blood pressure)

Side effects of Lok 50 Plus

Common
  • Nausea
  • Taste change
  • Upset stomach
  • Diarrhea
  • Headache
  • Dizziness
  • Weakness
  • Decreased blood pressure
  • Increased blood uric acid
  • Increased blood lipid level
  • Glucose intolerance
  • Electrolyte imbalance

How to use Lok 50 Plus

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Lok 50 Plus may be taken w... View More

How Lok 50 Plus works

Lok 50 Plus is a combination of two medicines: Losartan and Hydrochlorothiazide, which lowers the blood pressure effectively. Losartan is an angiotensin... View More

quick tipsQuick Tips
  • You have been prescribed Lok 50 Plus for the treatment of high blood pressure.
  • It can be taken with or without food.
  • Lok 50 Plus may cause dehydration. Drink plenty of fluids and inform your doctor if you develop extreme thirst, very dry mouth or muscle weakness.
  • It may cause dizziness. Get up slowly when rising from a sitting or lying position.
  • Use of Lok 50 Plus during pregnancy or breastfeeding is unsafe.
  • It may also decrease the risk of stroke and heart attacks.
descriptionBrief Description

Indication

Hypertension, Stroke, risk reduction of hypertensive or LVH patients

Adult Dose

Hypertension Initial: 50 mg/12.5 mg PO qDay If dose titrated upward, do not to exceed final titration of 100 mg/25 mg PO qDay or 50 mg/12.5 mg PO q1... View More

Child Dose

Safety and efficacy not established

Renal Dose

Renal impairment CrCl <30 mL/min: Do not use thiazide-containing products; loop diuretic preferred CrCl >30 mL/min: No dosage adjustment required

Contraindication

Pregnancy, lactation; intravascular volume depletion.

Mode of Action

Hydrochlorothiazide increases renal excretion of sodium and chloride and reduces cardiac load. Losartan is an angiotensin II receptor (type AT1) antagon... View More

Precaution

Existing electrolyte disturbances; hepatic cirrhosis; severe hepatic failure; oedema; elderly (>75 yr); renal impairment; hepatic impairment; diabetes, ... View More

Side Effect

>10% Losartan Fatigue (14%),Hypoglycemia (14%),Chest pain (12%),Cough, incidence higher in previous cough related to ACE therapy (3-11%) 1-10% Los... View More

Interaction

Reduced excretion of lithium; effect of diuretic, natriuretic & other antihypertensive w/ NSAIDs including selective COX-2 inhibitors. Do not co-adminis... View More

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descriptionDisclaimer

The information provided herein is accurate, updated and complete as per the best practices of the Company. Please note that this information should not... View More