Beacon Pharmaceuticals Ltd.
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Consuming alcohol with Pemetrex does not cause any harmful side effects.
Pemetrex is unsafe to use during pregnancy as there is definite evidence of risk to the developing baby. However, the doctor may rarely prescribe it in ... View More
Pemetrex should be used with caution during breastfeeding. Breastfeeding should be held until the treatment of the mother is completed and the drug is e... View More
Pemetrex may cause side effects which could affect your ability to drive. Pemetrex may make you feel tired and this may affect your ability to drive.
Pemetrex should be used with caution in patients with kidney disease. Dose adjustment of Pemetrex may be needed. Please consult your doctor. Use of Peme... View More
Pemetrex is probably safe to use in patients with liver disease. Limited data available suggests that dose adjustment of Pemetrex may not be needed in t... View More
Pemetrex is used in the treatment of non-small cell lung cancer and malignant pleural mesothelioma. Pemetrex is given as an injection by a qualified me... View More
Uses of Pemetrex
- Non-small cell lung cancer
- Malignant pleural mesothelioma
Side effects of Pemetrex
- Sore throat
- Loss of appetite
- Stomatitis (Inflammation of the mouth)
- Hair loss
- Low blood platelets
- Anemia (low number of red blood cells)
- Decreased white blood cell count (neutrophils)
How to use Pemetrex
Your doctor or nurse will give you this medicine. Kindly do not self administer.
How Pemetrex works
Pemetrex interferes with the growth of DNA and RNA of the cancer cells by substituting their building blocks. It prevents the cancer cells from growing ... View More
- Use a reliable contraceptive method to prevent pregnancy while you are taking this medicine.
- Inform your doctor immediately if you notice any signs of infection such as fever, sore throat, rash or severe diarrhea.
Non-small cell lung cancer, Malignant pleural mesothelioma
IV Preparation Aseptically reconstitute with 20 mL of 0.9% NaCl (preservative free) to give a 25 mg/mL solution Gently swirl until completely dissolve... View More
Intravenous Malignant Pleural Mesothelioma Indicated for mesothelioma in combination with cisplatin in patients whose disease is unresectable or are n... View More
Safety and efficacy not established
Renal impairment: CrCl (ml/min) Dosage Recommendation <45 Usage is not recommended.
Mode of Action
Pemetrexed is a thymidylate synthase inhibitor. It works by inhibiting thymidylate synthase, dihydrofolate reductase, glycinamide ribonucleotide formylt... View More
Monitor CBC, platelet counts, and CrCl for nadir and recovery before each cycle. Periodic hepatic monitoring Premedication with folate and vitamin B12 a... View More
>10% Nausea (84%),Fatigue (80%),Pulmonary dyspnea (66%),Neutropenia (58%),Vomiting (58%),Leukopenia (55%),Constipation (44%),Chest pain (40%),Anorexia ... View More
High doses of NSAIDs and aspirin may reduce the elimination of pemetrexed; avoid usage 2 days (5 days for longer-acting NSAIDs) before, during and 2 day... View More
Alternative brand for Pemetrex
The information provided herein is accurate, updated and complete as per the best practices of the Company. Please note that this information should not... View More