Intobac300mg/5ml

Indication

Cystic fibrosis

Adult Dose

Inhalation Cystic fibrosis Indicated for management Pseudomonas aeruginosa in patients with cystic fibrosis Adult: One single-use ampoule (300 mg) 1... View More

Child Dose

Inhalation Cystic fibrosis Indicated for management Pseudomonas aeruginosa in patients with cystic fibrosis Child: >6 yr : 300 mg 12 hrly, inhaled fr... View More

Renal Dose

Renal impairment: Dosage adjustment needed.

Contraindication

Hypersensitivity to aminoglycosides; pregnancy.

Mode of Action

Tobramycin acts by binding to 30S ribosomal subunits thus interfering with bacterial protein synthesis. It is active against many aerobic gram-negative ... View More

Precaution

Preexisting renal and auditory or vestibular impairment; dehydration; neuromuscular blockade, muscular disorders (e.g. myasthenia gravis, parkinsonism);... View More

Side Effect

>10% Voice alteration (12.8%) 1-10% Myalgia (4.7%),Laryngitis (4.3%),Tinnitus (3%),Epistaxis (3%)

Interaction

Increased nephrotoxicity or ototoxicity with etacrynic acid, furosemide, other aminoglycosides, cefalotin, cisplatin, vancomycin, piperacillin, ciclospo... View More