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Leukeran2mg

Tablet
Generic: Chlorambucil
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descriptionSafety Advices
AlcoholAlcohol
CONSULT YOUR DOCTOR
It is not known whether it is safe to consume alcohol with Leukeran. Please consult your doctor.
PregnancyPregnancy
CONSULT YOUR DOCTOR
Leukeran may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developin... View More
BreastfeedingBreastfeeding
UNSAFE
Leukeran is unsafe to use during breastfeeding. Data suggests that the drug may cause toxicity to the baby.
DrivingDriving
CONSULT YOUR DOCTOR
It is not known whether Leukeran alters the ability to drive. Do not drive if you experience any symptoms that affect your ability to concentrate and re... View More
KidneyKidney
CAUTION
Leukeran should be used with caution in patients with kidney disease. Dose adjustment of Leukeran may be needed. Please consult your doctor. Careful mon... View More
LiverLiver
CONSULT YOUR DOCTOR
There is limited information available on the use of Leukeran in patients with liver disease. Please consult your doctor.
descriptionMedical Overview

Introduction

Leukeran is used in the treatment of some cancers of blood and lymphatic system. It may be also used to treat other kinds of cancer, as determined by th... View More

Uses of Leukeran

  • Blood cancer
  • Hodgkin’s disease

Side effects of Leukeran

Common
  • Anemia (low number of red blood cells)
  • Decreased blood cells (red cells, white cells, and platelets)
  • Decreased white blood cell count (neutrophils)
  • Decreased white blood cell count
  • Bone marrow suppression
  • Nausea
  • Vomiting
  • Diarrhea
  • Mouth ulcer

How to use Leukeran

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Leukeran is to be taken em... View More

How Leukeran works

Leukeran is an anti-cancer medication. It works by damaging the genetic material (DNA and RNA) of the cancer cells. This stops their growth and multipli... View More

What if you forget to take Leukeran?

If you miss a dose of Leukeran, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your ... View More

quick tipsQuick Tips
  • Leukeran should be taken one hour before a meal or two hours after a meal.
descriptionBrief Description

Indication

Lymphocytic leukemia, non-Hodgkin lymphoma, Waldenstrm macroglobulinemia, polycythemia vera, trophoblastic neoplasms, ovarian carcinoma, nephrotic syndr... View More

Administration

Should be taken on an empty stomach. Take on an empty stomach. Ensure adequate hydration. Swallow whole, do not chew/crush.

Adult Dose

Chronic Lymphatic (Lymphocytic) Leukemia 0.1 mg/kg/day for 3-6 weeks or 0.4 mg/kg (increased by 0.1 mg/kg/dose until response/toxicity observed) biw... View More

Renal Dose

Renal Impairment <1% (including metabolites) excreted in urine; no dose adjustment required

Contraindication

Hypersensitivity. Pregnancy and lactation. Porphyria.

Mode of Action

Chlorambucil interferes with DNA replication and RNA transcription by alkylation and cross-linking cellular DNA strands, thus leading to disruption of t... View More

Precaution

Renal or hepatic dysfunction. Perform blood counts regularly. Seizure disorder, bone marrow suppression. Patient who has received radiation therapy, mye... View More

Side Effect

>10% Neutropenia (25-33%),Anemia,Leukopenia,Thrombocytopenia Frequency Not Defined Seizures,Hallucinations,Peripheral neuropathy,Nausea,Vomiting,Pu... View More

Pregnancy Category Note

Pregnancy Category: D Lactation: not known if excreted in breast milk; do not nurse

Interaction

Impairs immune response to vaccines, possible infection after admin of live vaccines.

descriptionDisclaimer

The information provided herein is accurate, updated and complete as per the best practices of the Company. Please note that this information should not... View More