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Generic: Peginterferon Alfa-2a
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descriptionMedical Overview


Chronic hepatitis C, Chronic hepatitis B


Administer by SC injection once weekly in abdomen or thigh

Adult Dose

Subcutaneous Chronic hepatitis C Adult: 180 mcg SC once weekly for 48 weeks Treatment duration Monotherapy: 48 weeks Dual therapy with Ribavirin... View More

Child Dose

Chronic Hepatitis C Indicated in combination with ribavirin for treatment of chronic hepatitis C of children aged >5 yr with CHC and compensated liver ... View More

Renal Dose

Renal impairment CrCl 30-50 mL/min: 180 mcg once weekly CrCl <30 mL/min (including patients on hemodialysis): 135 mcg once weekly If severe adverse r... View More


Hypersensitivity to any component of the product. Autoimmune hepatitis; decompensated liver disease in cirrhotic patients (Child-Pugh score >6); decompe... View More

Mode of Action

Peginterferon alfa-2a are interferon proteins bound to polyethylene glycol (PEG) molecules resulting in higher and more prolonged serum interferon conce... View More


Neuropsychiatric disorders, discontinue treatment with worsening or persistently severe signs/symptoms; myelosuppresion; anemia (spherocytosis, history ... View More

Side Effect

>10% Fatigue (24% to 67% ),Headache (27% to 54% ),Fever (24% to 54% ),Myalgia (26% to 51% ),Influenza-like illness (25% to 47% ),Rigor (25% to 47% ),Ne... View More

Pregnancy Category Note

Pregnancy Category: C (monotherapy); X (with ribavirin)


Increased risk of haemolytic anemia, birth defects and/or foetal mortality, genotoxicity, mutagenicity, and may possibly be carcinogenic with ribavirin;... View More


The information provided herein is accurate, updated and complete as per the best practices of the Company. Please note that this information should not... View More