Serivan 1717mg

Indication

Indicated for treatment of, hallucinations, delusions, associated with, Parkinson disease, psychosis

Administration

May take with or without food

Adult Dose

Parkinson Disease Psychosis Indicated for treatment of hallucinations and delusions associated with Parkinson disease psychosis 34 mg PO qDay (witho... View More

Renal Dose

Renal impairment Mild-to-moderate (CrCl ?30 mL/min): No dosage adjustment required Severe (CrCl <30 mL/min) or end stage renal disease: Use with cau... View More

Contraindication

Documented hypersensitivity reaction to drug or components; rash, urticaria, and reactions consistent with angioedema (e.g., tongue swelling, circumoral... View More

Mode of Action

Selective serotonin inverse agonist and antagonist activity preferentially targeting 5-HT2A receptors believed to play an important role in psychosis

Precaution

Antipsychotic drugs increase the all-cause risk of death in elderly patients with dementia-related psychosis Pimavanserin is a substrate of CYP3A4; s... View More

Side Effect

1-10% Nausea (7%) Peripheral edema (7%) Confusional state (6%) Hallucinations (5%) Constipation (4%) Gait disturbance (2%)

Pregnancy Category Note

Pregnancy There are no data for use in pregnant women that would allow assessment of the drug-associated risk of major congenital malformations or misc... View More