Introduction
Topita 100 SR is a medicine used to treat moderate to severe acute pain in adults. It is used to treat many conditions such as headache, fever, period pain, toothache, and colds. It effectively alleviates pain when other treatments fail to relieve your pain.
Topita 100 SR may be prescribed alone or in combination with another medicine. You should take it regularly as advised by your doctor. It can be taken with or without food. Your doctor may change the dose and time between doses according to your pain level and your needs. Do not take more or use it for longer than recommended by your doctor.
Some common side effects of this medicine includes nausea, sleepiness, vomiting, dizziness, headache, and constipation. If any of these side effects bother you or do not go away, you should let your doctor know. Your doctor may help with ways to reduce or prevent these symptoms by prescribing you an alternative medicine or by adjusting the dose.
The medicine may not be suitable for everybody. Before taking it, let your doctor know if you have any problems with your heart, kidneys, and liver. You should avoid consumption of alcohol while on this medication. Let your doctor know about all the other medicines you are taking because they may affect, or be affected by this medicine. Pregnant and breastfeeding mothers should consult their doctors before using this medicine as it can cause harmful effects to the developing baby.
Side effects of Topita 100 SR
Common
- Nausea
- Sleepiness
- Vomiting
- Dizziness
How to use Topita 100 SR
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Topita 100 SR may be taken with or without food, but it is better to take it at a fixed time.
How Topita 100 SR works
Topita 100 SR decreases the perception of pain by blocking the transmission of pain signals to the brain.
What if you forget to take Topita 100 SR?
If you miss a dose of Topita 100 SR, skip it and continue with your normal schedule. Do not double the dose.
Indication
Acute Moderate-to-Severe Pain, Musculoskeletal pain, Diabetic Peripheral Neuropathy
Administration
May be taken with or without food.
Adult Dose
Oral
Moderate to severe acute pain
Adult: Initially, 50 mg, 75 mg or 100 mg 4-6 hrly, depending on pain intensity.
On day 1, a 2nd dose may be given 1 hr after the initial dose if pain relief is inadequate; subsequent dose may be given 4-6 hrly, adjust according to response.
Max: 700 mg on day 1, 600 mg daily on subsequent days.
Elderly: Initiate dosage at lower end of range
Hepatic impairment
Mild: Dosage adjustment not required
Moderate: 50 mg q8hr initially; dosing frequency not to exceed 3 times daily;
Severe: Not recommended
Child Dose
Safety and efficacy not established
Renal Dose
Renal impairment
CrCl >30 mL/min : Dosage adjustment not required
CrCl <30 mL/min: Not recommended
Contraindication
Significant resp depression (in unmonitored settings or absence of resuscitative equipment), acute or severe bronchial asthma or hypercapnia, known or suspected paralytic ileus; acute intoxication w/ alcohol, hypnotics, centrally acting analgesics or psychotropic active substances. Concurrent or recent (w/in 2 wk) therapy w/ MAOIs.
Mode of Action
Mu-opioid agonist; inhibits ascending pain pathways, thus altering response to pain; produces analgesia, respiratory depression, and sedation; also inhibits reuptake of norepinephrine, which also affects ascending pain pathways.
Precaution
Tapentadol should be administered with caution to patients with conditions accompanied by hypoxia, hypercapnia, respiratory problems such as: asthma, chronic obstructive pulmonary disease etc. Besides this, in case of patient with sleep apnea syndrome, myxedema, kyphoscoliosis, central nervous system (CNS) depression should have to be cautious prior administration of Tapentadol. Patients receiving other µ-opioid agonist analgesics, general anesthetics, phenothiazines, other tranquilizers, sedatives, hypnotics, or other CNS depressants (including alcohol) concomitantly with Tapentadol may exhibit additive CNS depression.
Side Effect
>10%
Nausea (30%),Dizziness (24%),Vomiting (18%),Somnolence (15%)
1-10% (selected)
Constipation (8%),Pruritus (5%),Xerostomia (4%),Fatigue (3%),Hyperhidrosis (3%),Anorexia (2%),Dyspepsia (2%),Insomnia (2%)
Interaction
Potential severe adverse effects w/ MAOIs. CNS-active drugs; other serotonergic agents (including triptans, SSRIs, other SNRIs, lithium, sibutramine, fentanyl & its analogues, tramadol, dextromethorphan, tapentadol, meperidine, methadone, pentazocine or St. John's wort), drugs which impair serotonin (eg linezolid & methylene blue) or serotonin precursors (eg tryptophan supplements). Increased risk of QTc prolongation &/or ventricular arrhythmias w/ some antipsychotics & antibiotics.
Decreased AUC & Cmax of indinavir. Increased AUC & Cmax of haloperidol. Increased plasma conc w/ ketoconazole. Increased plasma conc & reduced BP-lowering effect of metoprolol. Increased AUC of risperidone. Reduced metabolism w/ CYP2D6 inhibitors. Increased venlafaxine levels w/ CYP3A4 inhibitors.