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Danlene 2525mg

Capsule
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Incepta Pharmaceuticals Ltd.
Generic: Dantrolene Sodium
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descriptionMedical Overview

Indication

Muscle tightness, muscle cramping (spasms), muscle pain caused by spinal cord injury, stroke, cerebral palsy, multiple sclerosis.

Administration

May be taken with or without food.

Adult Dose

Oral Spasticity Adult: Initially, 25 mg daily increased gradually at 7-day intervals over 7 wk. Discontinue if no response after 45 days of treatment.... View More

Child Dose

Oral Spasticity Child: Initially, 0.5 mg/kg once daily, may increase gradually to 2 mg/kg 3-4 times daily. Max: 100 mg 4 times daily.

Contraindication

Active liver disease; acute muscle spasm; patients who use their spasticity to maintain posture or function. Lactation.

Mode of Action

Dantrolene has a direct action on skeletal muscle. It uncouples muscular contraction from excitation, probably by interfering with calcium release from ... View More

Precaution

Perform LFTs before and during treatment. Increased risk of liver injury in patients >30 yr, female patients especially those on oestrogen therapy, hist... View More

Side Effect

Fatigue, muscle weakness/pain. GI disturbances, CNS effects, tachycardia, unstable BP, dyspnoea, drowsiness, rashes, pruritus, chills and fever, visual ... View More

Pregnancy Category Note

Pregnancy Category: C Lactation: enters breast milk/not recommended

Interaction

CNS depressants; oestrogens; calcium-channel blockers. CNS effects enhanced by alcohol or CNS depressants.

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descriptionDisclaimer

The information provided herein is accurate, updated and complete as per the best practices of the Company. Please note that this information should not... View More