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Metglip DS 5/5005mg+500mg

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Pacific Pharmaceuticals Ltd.
Generic: Glipizide + Metformin Hydrochloride
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descriptionSafety Advices
It is unsafe to consume alcohol with Metglip DS 5/500.
Metglip DS 5/500 may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the d... View More
Metglip DS 5/500 is probably safe to use during breastfeeding. Limited human data suggests that the drug does not represent any significant risk to the ... View More
Your ability to drive may be affected if your blood sugar is too low or too high. Do not drive if these symptoms occur.
Metglip DS 5/500 should be used with caution in patients with kidney disease. Dose adjustment of Metglip DS 5/500 may be needed. Please consult your doc... View More
Metglip DS 5/500 should be used with caution in patients with liver disease. Dose adjustment of Metglip DS 5/500 may be needed. Please consult your doct... View More
descriptionMedical Overview


Metglip DS 5/500 belongs to a category of medicines known as anti-diabetic drugs. It is a combination of two medicines used to treat type 2 diabetes mel... View More

Uses of Metglip DS 5/500

  • Type 2 diabetes mellitus

Side effects of Metglip DS 5/500

  • Hypoglycemia (low blood glucose level)
  • Taste change
  • Nausea
  • Stomach pain
  • Diarrhea
  • Headache
  • Upper respiratory tract infection

How to use Metglip DS 5/500

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Metglip DS 5/500 is to be ... View More

How Metglip DS 5/500 works

Metglip DS 5/500 is a combination of two antidiabetic medicines: Glipizide and Metformin. Glipizide is a sulfonylurea which works by increasing the amou... View More

quick tipsQuick Tips
  • Monitor your blood sugar level regularly while you are taking this medicine.
  • It can cause hypoglycemia (low blood sugar level) when used with other antidiabetic medicines, alcohol or if you delay or miss a meal.
  • Inform your doctor about your diabetes treatment if you are due to have surgery under a general anesthetic.
  • Tell your doctor immediately if you experience any deep or rapid breathing or if you have persistent nausea, vomiting, and stomach pain as Metglip DS 5/... View More
  • Your doctor may check your liver function regularly. Inform your doctor if you develop symptoms such as abdominal pain, loss of appetite, or yellowing o... View More
descriptionBrief Description


Type 2 DM


Should be taken with food.

Adult Dose

Type 2 Diabetes Mellitus Initial treatment: start at 2.5 mg/250 mg (glipizide/metformin) PO qDay with food If fasting plasma glucose = 280-320 mg/dL: ... View More

Renal Dose

Renal impairment: Serum creatinine (SCr) >1.5 mg/dL (males) or >1.4 mg/dL (females) Obtain eGFR before starting metformin eGFR <30 mL/min/1.73 m²: Con... View More


Hypersensitivity. Type 2 diabetes mellitus; ketoacidosis; severe renal or hepatic insufficiency, diabetic coma, cardiac failure, recent MI, CHF. IDDM; s... View More

Mode of Action

Glipizide stimulates insulin release from pancreatic beta-cells and reduces gluconeogenesis in liver cells. It also increases insulin sensitivity at tar... View More


Hypoglycaemia, stress, elderly. Thyroid impairment, monitor blood-glucose conc and renal function regularly. Lactation: enters breast milk; not recom... View More

Side Effect

Glipizide: GI upsets, diarrhoea, nausea; allergic skin reactions, leucopaenia, thrombocytopaenia, agranulocytosis, hyponatraemia; jaundice; haemolytic a... View More


Glipizide: Decreased effect with beta-blockers, cholestyramine, hydantoins, thiazide diuretics and urinary alkalinizers. Metformin: Additive effect wit... View More


The information provided herein is accurate, updated and complete as per the best practices of the Company. Please note that this information should not... View More