Mitomycin-C
Tablet
Additional Offers
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| Alcohol | UNSAFE Mitomycin-C may cause excessive drowsiness with alcohol. |
| Pregnancy | UNSAFE Mitomycin-C is highly unsafe to use during pregnancy. Seek your doctor's advice as studies on pregnant women and animals have shown significant harmful ... View More |
| Breastfeeding | CAUTION Mitomycin-C should be used with caution during breastfeeding. Breastfeeding should be held until the treatment of the mother is completed and the drug i... View More |
| Driving | UNSAFE Mitomycin-C may cause side effects which could affect your ability to drive.
Mitomycin-C may cause nausea and vomiting and thereby reduce your reaction ... View More |
| Kidney | CAUTION Mitomycin-C should be used with caution in patients with kidney disease. Dose adjustment of Mitomycin-C may be needed. Please consult your doctor.
Use o... View More |
| Liver | CAUTION Mitomycin-C should be used with caution in patients with liver disease. Dose adjustment of Mitomycin-C may be needed. Please consult your doctor.
Use of... View More |
Introduction
Mitomycin-C is used in the treatment of certain kinds of cancer of pancreas, breast, lung, and stomach. It can be used alone or in combination with some... View More
Uses of Mitomycin-C
- Pancreatic cancer
- Breast cancer
- Non-small cell lung cancer
- Stomach cancer
Side effects of Mitomycin-C
- Anemia (low number of red blood cells)
- Decreased white blood cell count
- Increased bleeding tendency
- Loss of appetite
- Nausea
- Vomiting
- Feeling of discomfort
- Low blood platelets
- Weight loss
- Rash
How to use Mitomycin-C
Your doctor or nurse will give you this medicine. Kindly do not self administer.
How Mitomycin-C works
Mitomycin-C is an anti-cancer medication. It works by damaging the genetic material (DNA) of the cancer cells and stops their growth and multiplication.... View More
- Inform your doctor if you have any of the following medical conditions: kidney disease; heart disease; or asthma, chronic obstructive pulmonary disease ... View More
- Before you take mitomycin, inform your doctor if have /are being treated for kidney disease, bleeding disorder or blood disorder.
- Take precautions as mitomycin can lower the ability of your body to fight infections and the ability of your blood to clot. You may get an infection or ... View More
- Seek immediate medical attention if you notice any redness, sores, oozing, or other skin changes during or after your treatment with mitomycin. Skin cha... View More
- Do not drive or operate machinery as mitomycin may cause weakness and lethargy.
- Tell your doctor if you are or planning to become pregnant or are breastfeeding.
Indication
Solid tumours, non-invasive bladder cancer, stomach cancer, pancreas cancer, metastatic breast cancer, advanced cervical cancer, anal carcinoma
Administration
IV Preparation Reconstitute with SWI to a concentration of 0.5 mg/mL IV Administration Administer slow IV push by central line only Flush with 5-1... View More
Adult Dose
Intravenous Solid tumours The usual dose is in the range of 4-10 mg (0.06-0.15 mg/kg) given at 1-6 weekly intervals depending on whether other drugs ... View More
Child Dose
Safety and efficacy not established
Renal Dose
Renal Impairment Serum creatinine >1.7 mg/dL: Avoid use CrCl <10 mL/min: Decrease dose by 25% CAPD: Decrease dose by 25%
Contraindication
Hypersensitivity. Patient w/ platelet counts <100,000/mm3, leukocyte counts <4,000/mm3 or serum creatinine concentration >1.7 mg/dL. Patient w/ substant... View More
Mode of Action
Mitomycin is an antineoplastic antibiotic which is enzymatically reduced to its active metabolite w/in susceptible cells. The active metabolite appears ... View More
Precaution
Patient w/ bone marrow depression, infections including varicella infection. Hepatic or renal impairment. Patient Counselling This drug may cause genera... View More
Side Effect
>10% Hemolytic uremic syndrome (≤15%),Myelosuppression (64%),Nausea/vomiting (14%),Fever (14%) 1-10% Stomatitis (4%),Increased serum creatinine (2%... View More
Interaction
Increased incidence of cardiotoxicity w/ doxorubicin. Potentially Fatal: Increased risk of intravascular haemolysis and renal failure w/ fluorouracil... View More
The information provided herein is accurate, updated and complete as per the best practices of the Company. Please note that this information should not... View More