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Lastet100mg/5ml

Injection
rx_reqRequire Prescription
Generic: Etoposide
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descriptionSafety Advices
AlcoholAlcohol
CONSULT YOUR DOCTOR
It is not known whether it is safe to consume alcohol with Lastet. Please consult your doctor.
PregnancyPregnancy
CONSULT YOUR DOCTOR
Lastet is unsafe to use during pregnancy as there is definite evidence of risk to the developing baby. However, the doctor may rarely prescribe it in so... View More
BreastfeedingBreastfeeding
UNSAFE
Lastet is unsafe to use during breastfeeding. Data suggests that the drug may cause toxicity to the baby.
DrivingDriving
SAFE
Lastet does not usually affect your ability to drive.
KidneyKidney
CAUTION
Lastet should be used with caution in patients with kidney disease. Dose adjustment of Lastet may be needed. Please consult your doctor. Use of Lastet i... View More
LiverLiver
CAUTION
Lastet should be used with caution in patients with liver disease. Dose adjustment of Lastet may be needed. Please consult your doctor. Use of Lastet is... View More
descriptionMedical Overview

Introduction

Lastet is used to treat different cancers of lung, and testicles. It is also sometimes used to treat some other kinds of cancer in both men and women. I... View More

Uses of Lastet

  • Small cell lung cancer
  • Testicular cancer

Side effects of Lastet

Common
  • Anemia (low number of red blood cells)
  • Decreased blood cells (red cells, white cells, and platelets)
  • Decreased white blood cell count
  • Diarrhea
  • Hair loss
  • Liver damage
  • Low blood platelets
  • Nausea
  • Rash
  • Stomatitis (Inflammation of the mouth)
  • Vomiting

How to use Lastet

Your doctor or nurse will give you this medicine. Kindly do not self administer.

How Lastet works

Lastet is an anti-cancer medication. It works by suppressing the activity of an enzyme (topoisomerase II) involved in DNA multiplication of the cancer c... View More

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descriptionBrief Description

Indication

Lung cancer, Testicular cancer

Adult Dose

Intravenous Testicular Cancer 50-100 mg/m²/day IV on days 1-5, OR 100 mg/m²/day IV on days 1, 3, 5 Repeat q3-4week Small-Cell Lung Cancer 35 mg... View More

Renal Dose

Renal Impairment CrCl >50 mL/min: Dose adjustment not necessary CrCl 15-50 mL/min: 75% of regular dose CrCl < 15 mL/min: Not studied; consider furthe... View More

Contraindication

Hypersensitivity, pregnancy, lactation.

Mode of Action

Etoposide is a derivative of podophyllotoxin that inhibits DNA synthesis resulting in the arrest of the cell cycle. At low doses, it inhibits cells from... View More

Precaution

Skin reactions may occur with accidental exposure; renal or hepatic disease. Periodic CBCs should be done before, during and after therapy. Increased ri... View More

Side Effect

>10% Leukopenia (60-91%),Nausea and Vomiting (30-40%),Thrombocytopenia (28-41%),Alopecia (20-90%),Anorexia (13%),Diarrhea (13%),Leukopenia (60-91%),Ane... View More

Pregnancy Category Note

Pregnancy: Based on animal data and its mechanism of action, etoposide can cause fetal harm when administered to a pregnant woman; etoposide, the active... View More

Interaction

Synergism with other cytotoxic drugs. Caution when admin with drugs that inhibit phosphatase activity. Cyclosporin A may reduce the clearance of etoposi... View More

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descriptionDisclaimer

The information provided herein is accurate, updated and complete as per the best practices of the Company. Please note that this information should not... View More