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Grafil30MIU/.5ml

Injection
rx_reqRequire Prescription
Drug International Ltd.
Generic: Filgrastim
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descriptionSafety Advices
AlcoholAlcohol
CONSULT YOUR DOCTOR
It is not known whether it is safe to consume alcohol with Grafil. Please consult your doctor.
PregnancyPregnancy
CONSULT YOUR DOCTOR
Grafil may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing ... View More
BreastfeedingBreastfeeding
SAFE IF PRESCRIBED
Grafil is probably safe to use during breastfeeding. Limited human data suggests that the drug does not represent any significant risk to the baby.
DrivingDriving
UNSAFE
Grafil may cause side effects which could affect your ability to drive. Grafil may cause fatigue. This may affect your driving ability.
KidneyKidney
SAFE IF PRESCRIBED
Grafil is safe to use in patients with kidney disease. No dose adjustment of Grafil is recommended.
LiverLiver
SAFE IF PRESCRIBED
Grafil is safe to use in patients with liver disease. No dose adjustment of Grafil is recommended.
descriptionMedical Overview

Introduction

Grafil is used to prevent infections after chemotherapy. It is a growth factor that stimulates the bone marrow to produce white blood cells. These cells... View More

Uses of Grafil

  • Infections after chemotherapy

Side effects of Grafil

Common
  • Bone pain
  • Weakness
  • Headache
  • Rash
  • Nausea
  • Increased lactate dehydrogenase level in blood
  • Vomiting
  • Increased uric acid level in blood
  • Oropharyngeal pain
  • Hair loss
  • Fatigue
  • Diarrhea
  • Constipation
  • Decreased appetite
  • Cough
  • Breathing problems

How to use Grafil

Your doctor or nurse will give you this medicine. Kindly do not self administer.

How Grafil works

Grafil is a growth factor that stimulates the bone marrow to produce white blood cells. These cells protect the body against infections. .

What if you forget to take Grafil?

If you miss a dose of Grafil, please consult your doctor.

quick tipsQuick Tips
  • Grafil reduces the risk of infection in people treated with chemotherapy.
  • It is usually given as a daily injection into the tissue just under the skin or into the vein.
  • You will normally receive your first dose at least 24 hours after your chemotherapy or bone marrow transplant.
  • Store it in the refrigerator, protect it from light, and don't shake it.
  • For a more comfortable injection, leave the syringe at room temperature for 30 minutes before using it.
  • Pain or redness in the area of injection is common. Let your doctor know if you notice a lump, swelling, or bruising that doesn't go away.
  • Use caution while driving or doing anything that requires concentration as Grafil may cause dizziness.
  • Your doctor may get regular tests done to monitor the number of blood cells in your blood, and your bone density level while you are receiving treatment... View More
  • Stop taking Grafil and inform your doctor if you have a fever, shortness of breath, fast rate of breathing or trouble breathing.
descriptionBrief Description

Indication

Myelosuppressive chemotherapy, Acute Myeloid Leukemia, receiving induction or consolidation chemotherapy, Peripheral blood progenitor cell collection an... View More

Administration

IV Preparation Vials may be diluted in D5W to >15 mcg/mL for infusion 5-15 mcg/mL dilution: Protect from adsorption to plastic materials by the additi... View More

Adult Dose

Parenteral Chemotherapy-induced neutropenia Adult: 5 mcg/kg daily as a single daily SC inj, as a continuous IV or SC infusion, or as a daily IV infusi... View More

Contraindication

Hypersensitivity to E. coli derived proteins, Filgrastim or any component of the product. Myeloid malignancies. Not to be used within 24 hr of cytotoxic... View More

Mode of Action

Filgrastim is a granulocyte-colony stimulating factor which binds to cell surface receptors on haemetopoietic cells thus stimulating the development of ... View More

Precaution

Filgrastim should not be administered within 24 hours before and after chemotherapy. Premalignant or malignant myeloid condition; sickle-cell disease; o... View More

Side Effect

>10% Nausea (57%),Vomiting (57%),Bone pain (22%-33%),Alopecia (18%),Diarrhea (14%),Fever (12%),Fatigue (11%) 1-10% Headache,Anorexia,Chest pain,Cou... View More

Pregnancy Category Note

Pregnancy Available data from published studies, including several observational studies of pregnancy outcomes in women exposed to filgrastim products ... View More

Interaction

Myelosuppressive antineoplastic agents. Drugs which may potentiate the release of neutrophils e.g. lithium.

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descriptionDisclaimer

The information provided herein is accurate, updated and complete as per the best practices of the Company. Please note that this information should not... View More