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Epiruba-502mg/ml

Injection
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Drug International Ltd.
Generic: Epirubicin Hydrochloride
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descriptionSafety Advices
AlcoholAlcohol
UNSAFE
It is unsafe to consume alcohol with Epiruba-50.
PregnancyPregnancy
CONSULT YOUR DOCTOR
Epiruba-50 is unsafe to use during pregnancy as there is definite evidence of risk to the developing baby. However, the doctor may rarely prescribe it i... View More
BreastfeedingBreastfeeding
UNSAFE
Epiruba-50 is unsafe to use during breastfeeding. Data suggests that the drug may cause toxicity to the baby.
DrivingDriving
UNSAFE
Epiruba-50 may cause side effects which could affect your ability to drive. Epiruba-50 may cause episodes of nausea and vomiting, which can temporarily ... View More
KidneyKidney
SAFE IF PRESCRIBED
Epiruba-50 is probably safe to use in patients with kidney disease. Limited data available suggests that dose adjustment of Epiruba-50 may not be needed... View More
LiverLiver
CAUTION
Epiruba-50 should be used with caution in patients with liver disease. Dose adjustment of Epiruba-50 may be needed. Please consult your doctor. Use of E... View More
descriptionMedical Overview

Introduction

Epiruba-50 is used in the treatment of various types of cancers of blood, breast, stomach, lung, ovaries and soft tissues. It also helps to prevent the ... View More

Uses of Epiruba-50

  • Cancer

Side effects of Epiruba-50

Common
  • Low blood platelets
  • Nausea
  • Hair loss
  • Absence of menstrual periods
  • Fever
  • Anemia (low number of red blood cells)
  • Diarrhea
  • Weight loss
  • Decreased white blood cell count (neutrophils)
  • Hot flashes
  • Gastrointestinal inflammation
  • Rash
  • Low energy
  • Eye disorder

How to use Epiruba-50

Your doctor or nurse will give you this medicine. Kindly do not self administer.

How Epiruba-50 works

Epiruba-50 is an anti-cancer medication. It works by suppressing the activity of an enzyme (topoisomerase II) involved in DNA multiplication of the brea... View More

quick tipsQuick Tips
  • Epiruba-50 is used alone or in combination with other medicines for the treatment of various types of cancers.
  • It is given through a drip into a vein (intravenous infusion) by a doctor or nurse.
  • It may make you feel tired or sleepy. Do not drive or do anything that requires mental focus until you know how it affects you.
  • Use a reliable contraceptive method to prevent pregnancy while you are taking this medicine and for 6 months after stopping treatment.
  • Your doctor may get regular blood tests done to monitor your blood cells, liver, and heart function during treatment with this medicine.
  • Inform your doctor immediately if you notice any signs of infection such as fever, sore throat or rash.
descriptionBrief Description

Indication

Acute leukaemias; Lymphoma; Multiple myeloma, Breast cancer, Bladder carcinoma

Administration

IV Administration Administer infuse into tubing of a freely flowing infusion (NS or D5W) over 3-5 min Avoid extravasation, associated with severe ulce... View More

Adult Dose

Adjuvant Breast Cancer Treatment Option 1 (Day 1 dose schedule) Day 1: Epirubicin 100 mg/m² IV, AND 5-fluorouracil 500 mg/m² IV, AND cyclophosphamide ... View More

Child Dose

Safety & efficacy not established

Renal Dose

Renal Impairment SCr >5 mg/dL [>442 micromoles/L]: Decrease dose by 50%; test cardiac ejection fraction via MUGA before starting treatment

Contraindication

Cardiac impairment, severe or recent MI; previous full cumulative doses of anthracyclines. Hypersensitivity; severe hepatic dysfunction. Not for intrave... View More

Mode of Action

Epirubicin, an anthracycline with cytotoxic properties. It inhibits DNA and RNA synthesis by steric obstruction after intercalating between DNA base pai... View More

Precaution

Previous extensive radiotherapy, bone infiltration by tumour, severe renal and hepatic dysfunction. May cause tumor lysis syndrome or radiation recall. ... View More

Side Effect

>10% Alopecia (96%),Nausea and vomiting (92%),Leukopenia or neutropenia (80%),Amenorrhea (72%),Anemia (72%),Mucositis (59%),Thrombocytopenia (49%),Leth... View More

Pregnancy Category Note

Pregnancy Verify pregnancy status in female patients of reproductive potential prior to initiating Based on findings from animal studies and mechani... View More

Interaction

Paclitaxel and other anthracyclines. Cimetidine, heparin. Antineoplastic drugs, cardiotoxic drugs, radiation, hepatoactive drugs.

descriptionDisclaimer

The information provided herein is accurate, updated and complete as per the best practices of the Company. Please note that this information should not... View More