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Lenvacent 44mg

Capsule
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Incepta Pharmaceuticals Ltd.
Generic: Lenvatinib
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670.00
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descriptionSafety Advices
AlcoholAlcohol
CONSULT YOUR DOCTOR
It is not known whether it is safe to consume alcohol with Lenvacent 4. Please consult your doctor.
PregnancyPregnancy
CONSULT YOUR DOCTOR
Lenvacent 4 may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the develo... View More
BreastfeedingBreastfeeding
CONSULT YOUR DOCTOR
Lenvacent 4 is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.
DrivingDriving
CONSULT YOUR DOCTOR
It is not known whether Lenvacent 4 alters the ability to drive. Do not drive if you experience any symptoms that affect your ability to concentrate and... View More
KidneyKidney
CAUTION
Lenvacent 4 should be used with caution in patients with kidney disease. Dose adjustment of Lenvacent 4 may be needed. Please consult your doctor.
LiverLiver
CAUTION
Lenvacent 4 should be used with caution in patients with liver disease. Dose adjustment of Lenvacent 4 may be needed. Please consult your doctor.
descriptionMedical Overview

Introduction

Lenvacent 4 is an oral receptor tyrosine kinase inhibitor used in the treatment of thyroid cancer. Lenvacent 4 can be taken with or without food, but t... View More

Uses of Lenvacent 4

  • Thyroid cancer

Side effects of Lenvacent 4

Common
  • Bleeding
  • Cough
  • Decreased appetite
  • Erythema (skin redness)
  • Hoarseness of voice
  • Itching
  • Joint pain
  • Mouth sore
  • Muscle pain
  • Nausea
  • Peripheral edema
  • Rash
  • Skin peeling
  • Stomach pain
  • Tiredness
  • Vomiting
  • Weight loss

How to use Lenvacent 4

Take this medicine in the dose and duration as advised by your doctor. Do not chew, crush or break it. Lenvacent 4 may be taken with or without food, bu... View More

How Lenvacent 4 works

Lenvacent 4 is a tyrosine kinase inhibitor. It works by blocking the oxygen and nutrient supply to cancer cells due to which they stop growing.

quick tipsQuick Tips
  • Lenvacent 4 is used for the treatment of thyroid cancer.
  • Take it with or without food, preferably at the same time each day.
  • Diarrhea may occur as a side effect. Drink plenty of fluids and inform your doctor if it doesn't stop or if you find blood in your stools.
  • Use a reliable contraceptive method to prevent pregnancy while you are taking this medicine and for a month after you stop taking it.
  • Monitor your blood pressure regularly while taking this medication. Inform your doctor if you notice symptoms of very high blood pressure such as severe... View More
  • It may cause serious bleeding problem. Inform your doctor if you get headaches, stomach pain or if you notice blood in your urine or stools.
  • Do not take this medicine if you are pregnant, planning to conceive or breastfeeding.
descriptionBrief Description

Indication

Patients with locally recurrent or metastatic, progressive, radioactive iodine-refractory differentiated, thyroid cancer. In combination with everolimus... View More

Administration

Swallow capsule whole May take with or without food Take at the same time each day

Adult Dose

Adult Differentiated thyroid cancer (DTC) 24 mg once daily. Renal cell carcinoma (RCC) 18 mg in combination w/ everolimus 5 mg once daily. Patient... View More

Renal Dose

Patient w/ severe renal impairment Initially 14 mg once daily for DTC. 10 mg once daily for RCC.

Contraindication

Hypersensitivity. Lactation.

Mode of Action

Receptor tyrosine kinase (RTK) inhibitor that inhibits the kinase activities of vascular endothelial growth factor (VEGF) receptors VEGFR1 (FLT1), VEGFR... View More

Precaution

Monitor BP after 1 wk of treatment then every 2 wk for the 1st 2 month & monthly thereafter. Monitor urine protein regularly. Actively managed GI toxici... View More

Side Effect

>10% Percentages are for all grades of adverse effects unless otherwise noted Hypertension (73%),Diarrhea (67%),Fatigue (67%),Arthralgia/myalgia (62... View More

Interaction

Decreased exposure w/ oral CYP3A4/Pgp substrates [eg, astemizole, terfenadine, cisapride, pimozide, quinidine, bepridil or ergot alkaloids (ergotamine, ... View More

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descriptionDisclaimer

The information provided herein is accurate, updated and complete as per the best practices of the Company. Please note that this information should not... View More