Introduction
Budicort 0.5 Nebuliser Suspension is used to prevent the symptoms of asthma (wheezing and shortness of breath). It is a steroid and is known as a "preventer". You need to have a fast-acting “reliever” as well because this medicine will not stop an asthma attack that has already started.
Your doctor will tell you how often you need to use Budicort 0.5 Nebuliser Suspension. It is important that you take the lowest dose needed to effectively control your asthma. The effect of this medicine may be noticeable after a few days but will only reach its maximum after a few weeks. This medicine must be used regularly to be effective, so go on taking it even if you do not have any symptoms. No symptoms mean that the medicine is doing its job. If you stop taking it your asthma may get worse. It should not be used to relieve sudden asthma attacks. If an asthma attack occurs, use your quick-relief inhaler "reliever". To get the benefit from this medicine you need to make sure you get your inhaler technique right, otherwise, it will not work as well.
The most common side effects are irritation in the throat, difficulty swallowing and fungal infections in the mouth or throat. If you get these, do not stop taking it but do talk to your doctor. You can help prevent these symptoms by rinsing your mouth and throat with water or brushing your teeth after using your inhaler. There are other rare, side effects which can be serious. Talk to your doctor if you are worried about them. In general, you should be trying to avoid situations which make your asthma worse (your triggers) and try not to smoke.
Before taking Budicort 0.5 Nebuliser Suspension, you should tell your doctor if you have tuberculosis, any infections in your mouth or lungs, or liver disease. While taking it you may be more at risk of getting infections so stay away from people with colds and flu. If you use Budicort 0.5 Nebuliser Suspension for a long time it may cause weak bones (osteoporosis) and damage to your eyes (glaucoma or cataracts). You might need tests for bone density and eye pressure. Ask your doctor whether it's safe to take this medicine if you are pregnant or breastfeeding.
Uses of Budicort 0.5 Nebuliser Suspension
Side effects of Budicort 0.5 Nebuliser Suspension
Common
- Difficulty in swallowing
- Fungal infection
- Respiratory tract infection
How to use Budicort 0.5 Nebuliser Suspension
Use this medicine in the dose and duration as advised by your doctor. Check the label for directions before use. Twist off the top of the respule/transpule and squeeze all the liquid into the nebulizer. It should be used right away after opening.
How Budicort 0.5 Nebuliser Suspension works
Budicort 0.5 Nebuliser Suspension is a steroid. It prevents the cells in the lungs and breathing passages from releasing chemical messengers that cause inflammation (swelling) of the airways. This widens the airways and makes breathing easier.
What if you forget to take Budicort 0.5 Nebuliser Suspension?
If you miss a dose of Budicort 0.5 Nebuliser Suspension, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
Adult Dose
Inhalation
Asthma
Adult: As metered-dose aerosol: 400 mcg daily in 2 divided doses, increased up to 1.6 mg daily in severe cases. Maintenance: 200-400 mcg daily.
As dry powd inhaler: 200-800 mcg daily in single dose or in 2 divided doses. Max: 800 mcg bid.
As nebuliser soln: Severe asthma: 1-2 mg bid. Maintenance dose: 0.5-1 mg bid.
Child Dose
Inhalation
Asthma
Child: 2-12 yr As metered-dose aerosol: 200-800 mcg daily in divided doses.
5-12 yr As dry powd inhaler: 200-800 mcg daily in 2 divided doses.
3 mth to 12 yr As nebuliser soln: Initially, 0.5-1 mg bid.
Maintenance dose: 0.25-0.5 mg bid.
Inhalation
Croup
Child: As nebuliser soln: 2 mg as a single dose or as 2 doses of 1 mg w/ 30 min interval, may be repeated 12 hrly for a max of 36 hr or until clinical improvement is observed.
Contraindication
Hypersensitivity to any of the ingredients of this preparation.
Mode of Action
Budesonide controls the rate of protein synthesis, depresses the migration of polymorphonuclear leukocytes, fibroblasts, reverses capillary permeability and lysosomal stabilisation at the cellular level to prevent or control inflammation.
Precaution
Active or doubtfully quiescent tuberculosis, paradoxical bronchospasm; untreated fungal, bacterial, or systemic viral infections, or ocular herpes simplex infection.
Lactation: Drug enters breast milk; use only if benefits greatly outweigh risks
Side Effect
>10%
Respiratory infection (34-38%),Rhinitis (7-12%),Otitis media (1-12%)
1-10%
Nasopharyngitis (10%),Nasal congestion (3%),Pharyngitis (3%),Allergic rhinitis (2%),Viral gastroenteritis (2%),Viral upper respiratory tract infection (2%),Oral candidiasis (1%)
Pregnancy Category Note
Pregnancy
There are no adequate well-controlled studies in pregnant women; however, there are published studies on use of budesonide, in pregnant women; studies of pregnant women have not shown that inhaled budesonide increases risk of abnormalities when administered during pregnancy
There are no well-controlled human studies that have investigated effects of therapy during labor and delivery
Animal data
In animal reproduction studies, therapy, administered by subcutaneous route, caused structural abnormalities, was embryocidal, and reduced fetal weights in rats and rabbits at less than maximum recommended human daily inhalation dose (MRHDID), but these effects were not seen in rats that received inhaled doses approximately 2 times the MRHDID; experience with oral corticosteroids suggests that rodents are more prone to structural abnormalities from corticosteroid exposure than humans
In women with poorly or moderately controlled asthma, there is increased risk of several perinatal adverse outcomes such as preeclampsia in the mother and prematurity, low birth weight, and small for gestational age in neonate; pregnant women with asthma should be closely monitored and medication adjusted as necessary to maintain optimal asthma control
Lactation
There are no available data on effects of therapy on breastfed child or on milk production; budesonide, is present in human milk; developmental and health benefits of breastfeeding should be considered along with mother’s clinical need for therapy and any potential adverse effects on breastfed infant from drug or from underlying maternal condition
Interaction
Increased systemic exposure w/ potent CYP3A4 inhibitors (e.g. ketoconazole). Decreased systemic exposure w/ CYP3A4 inducers (e.g. carbamazepine).