Betrixa40mg

Indication

Venous Thromboembolism Prevention

Administration

Take with food at approximately the same time each day

Adult Dose

Venous Thromboembolism Prevention Indicated for prophylaxis of venous thromboembolism (VTE) in adults hospitalized for acute medical illness who are at... View More

Renal Dose

Renal impairment Mild-to-moderate (CrCl >30 mL/min): No dose adjustment needed Severe (CrCl >15 to <30 mL/min): Initial single dose of 80 mg, then 4... View More

Contraindication

Active pathological bleeding Severe hypersensitivity

Mode of Action

Oral factor Xa (FXa) inhibitor that selectively blocks the active site of FXa and does not require a cofactor (eg, antithrombin III) for activity; inhib... View More

Precaution

Increases bleeding risk and can cause serious and potentially fatal bleeding; promptly evaluate any signs or symptoms of blood loss; there is no establi... View More

Side Effect

1-10% Clinically relevant nonmajor bleeding (2.45%) Epistaxis (2%) Hematuria (2%) <1% Bleeding Major bleeding (0.67%) GI bleeding (0.51%)... View More

Pregnancy Category Note

Pregnancy No data exist with use in pregnant women, but treatment is likely to increase risk of hemorrhage during pregnancy and delivery Use during ... View More

Interaction

Coadministration with drugs affecting hemostasis increases bleeding risk; examples include aspirin and other antiplatelet agents, other anticoagulants, ... View More