Carplatin 450 is used in the treatment of ovarian cancer and small cell lung cancer. It shows its working by stopping or slowing down the growth of canc... View More
Uses of Carplatin 450
Side effects of Carplatin 450
How to use Carplatin 450
Your doctor or nurse will give you this medicine. Kindly do not self administer.
How Carplatin 450 works
Carplatin 450 is an anti-cancer medication. It works by damaging the genetic material (DNA and RNA) of the cancer cells which stops their growth and mul... View More
What if you forget to take Carplatin 450?
If you miss a dose of Carplatin 450, please consult your doctor.
Ovarian carcinoma, Lung cancer
IV Preparation Single-dose lyophilized powder (reconstitution require) Reconstitute powder with sterile water for injection, D5W, or 0.9% NaCl to yiel... View More
Intravenous Small cell lung cancer; Advanced ovarian carcinoma Adult: IV As single agent in treatment-naive patients: 400 mg/m2; As single agent in ... View More
Solid tumor 300-600 mg/m² IV q4Weeks Sarcoma (bone/soft tissue) 400 mg/m²/day for 2 days every 21 days Brain tumor 175 mg/m² qWeek x 4 weeks w... View More
Renal impairment: CrCl (ml/min) >40 Recommended dose: 400 mg/m2. 20-39 Recommended dose: 250 mg/m2.
Previous allergy; pregnancy, lactation; allergy to other platinum compounds; severe bone marrow depression; significant bleeding, aluminium containing n... View More
Mode of Action
Carboplatin is an alkylating agent which binds covalently to DNA. It modifies the cell cycle by interfering with DNA structure and function.
Neonates; diminished renal function; neurotoxicity; liver function impairment. Lactation: not known if excreted in breast milk; do not nurse
>10% Leukopenia (26-97%),Neutropenia (21-96%),Nausea (81-93%),Vomiting (81-93%),Anemia (14-90%),Magnesium loss (43-61%),Thrombocytopenia (33-66%),Alope... View More
Pregnancy Category Note
Pregnancy Category: D Lactation: not known if excreted in breast milk; do not nurse
Increased risk of ototoxicity when used with aminoglycosides.