Introduction
Carbizol 10 belongs to a group of medicine called anti-thyroid agents. It is used in the treatment of hyperthyroidism. It reduces the amount of thyroid hormones produced by the thyroid gland.
Carbizol 10 may be used alone or in combination with other medicines. It can be taken with or without food. It should be taken exactly as prescribed by your doctor. Your doctor will decide the dose and how often you should take them. You should take this medicine regularly to get the most benefit from it. Do not stop taking the medicine even if you feel better unless the doctor tells you so.
Taking this medicine may cause few common side effects such as skin rash, headache, skin pigmentation, and muscle pain or weakness. Let your doctor know if any of these do not go away with time or worse.
Before using this medicine, inform your doctor if you have any problems with your liver or kidneys. You should also tell your doctor all the other medications you are taking. Pregnant and breastfeeding mothers should consult their doctors before using the medicine.
Side effects of Carbizol 10
Common
- Skin rash
- Headache
- Skin pigmentation
- Pain
- Joint stiffness
- Nausea
- Paresthesia (tingling or pricking sensation)
- Hair loss
How to use Carbizol 10
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Carbizol 10 may be taken with or without food, but it is better to take it at a fixed time.
How Carbizol 10 works
Carbizol 10 is an anti-thyroid medication. It works by reducing the amount of thyroid hormones produced by the thyroid gland.
Indication
Grave's disease, Hyperthyroidism, Diabetic nephropathy, Preparation for thyroidectomy
Administration
May be taken with or without food. Take consistently w/ or w/o meals.
Adult Dose
Oral
Hyperthyroidism, Adjunct to radio-iodine therapy, Grave's disease, Preparation for thyroidectomy
Adult: Initially, 20-60 mg daily as a single or divided dose, reduced gradually once euthyroidism is achieved. Maintenance: 5-15 mg daily for at least 1 yr or 18 mth.
Hepatic impairment: Severe: Contraindicated.
Child Dose
Oral
Hyperthyroidism; Adjunct to radio-iodine therapy; Preparation for thyroidectomy
Child: 3-17 yr Initially, 15 mg daily, adjusted according to response.
Contraindication
Hyperthyroidism due to nodular goitre.
Mode of Action
Carbimazole is metabolised to methimazole which is responsible for its antithyroid action. It blocks the production of thyroid hormones by inhibiting thyroid peroxidase.
Precaution
Liver diseases, pregnancy, lactation.
Side Effect
Mild leucopaenia, sore throat, mouth ulcers, fever, bruising, malaise; rarely cholestatic jaundice; nephrotic syndrome. Nausea, loss of taste, headache, arthralgia, alopoecia.
Potentially Fatal: Agranulocytosis, aplastic anaemia, hypoprothrombinaemia, neutropaenia; hypothyroidism and goitre.
Interaction
Increased serum levels of theophylline or may develop toxicity. May enhance the effect of anticoagulants.
Potentially Fatal: Increased sensitivity to warfarin in hyperthyroidism and careful control required as patient is rendered euthyroid.