PMB500000IU

Indication

Susceptible infections, Meningitis

Administration

IV/IM/IT Preparation IV: dilute 500,000 U in 300-500 mL D5W IM: reconstitute vial with 2 mL SWI , NS, or procaine HCl 1% solution Intrathecal (IT... View More

Adult Dose

Intravenous Susceptible infections Adult: 15,000-25,000 U/kg daily by continuous IV drip or intermittent infusion 12 hrly at 60-120 min duration. Max:... View More

Child Dose

Intravenous Susceptible infections Adult: 15,000-25,000 U/kg daily by continuous IV drip or intermittent infusion 12 hrly at 60-120 min duration. Max:... View More

Renal Dose

Renal Impairment CrCl >20 mL/minute: give 75-100% usual dose/day divided q12hr CrCl 5-20 mL/minute: give 50% usual dose/day divided q12hr CrCl <5... View More

Contraindication

Hypersensitivity to polymyxins; Concurrent use w/ nephrotoxic and/or neurotoxic drugs and neuromuscular blockers.

Mode of Action

Polymyxin B binds to phospholipids, alters permeability and disrupts the bacterial cytoplasmic membrane of mostly gm-ve organisms allowing leakage of in... View More

Precaution

Oliguria, myasthenia gravis, pregnancy, renal disease Potential risk of nephrotoxicity and neurotoxicity May inhibit neuromuscular transmission ... View More

Side Effect

Frequency Not Defined Anaphylactoid reactions with dyspnea and tachycardia Eosinophilia Fever Nephrotoxicity Neurotoxicity Skin exanthem... View More

Pregnancy Category Note

Pregnancy Category: B: use when benefits outweigh risks Lactation: use caution; no data

Interaction

Potentially Fatal: Additive neurotoxic or nephrotoxic effect w/ bacitracin, streptomycin, neomycin, kanamycin, gentamicin, tobramycin, amikacin, cephalo... View More