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Mabthera 500500mg/10ml

Injection
rx_reqRequire Prescription
Roche Bangladesh Pharmaceutical
Generic: Rituximab
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descriptionSafety Advices
AlcoholAlcohol
CAUTION
Caution is advised when consuming alcohol with Mabthera 500. Please consult your doctor.
PregnancyPregnancy
CONSULT YOUR DOCTOR
Mabthera 500 may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the devel... View More
BreastfeedingBreastfeeding
SAFE IF PRESCRIBED
Mabthera 500 is probably safe to use during breastfeeding. Limited human data suggests that the drug does not represent any significant risk to the baby... View More
DrivingDriving
CONSULT YOUR DOCTOR
It is not known whether Mabthera 500 alters the ability to drive. Do not drive if you experience any symptoms that affect your ability to concentrate an... View More
KidneyKidney
SAFE IF PRESCRIBED
Mabthera 500 is probably safe to use in patients with kidney disease. Limited data available suggests that dose adjustment of Mabthera 500 may not be ne... View More
LiverLiver
CONSULT YOUR DOCTOR
There is limited information available on the use of Mabthera 500 in patients with liver disease. Please consult your doctor. Use of Mabthera 500 is not... View More
descriptionMedical Overview

Introduction

Mabthera 500 is used in the treatment of non-Hodgkin lymphoma (NHL), rheumatoid arthritis, blood cancer (chronic lymphocytic leukemia), granulomatosis w... View More

Uses of Mabthera 500

  • Non-Hodgkin lymphoma (NHL)
  • Rheumatoid arthritis
  • Blood cancer (Chronic lymphocytic leukemia)
  • Granulomatosis with polyangiitis
  • Microscopic polyangiitis

Side effects of Mabthera 500

Common
  • Headache
  • Weakness
  • Edema (swelling)
  • Infection
  • Hair loss
  • Itching
  • Chills
  • Febrile neutropenia
  • Decreased white blood cell count (neutrophils)
  • Infusion reaction
  • Increased risk of infection
  • Decreased blood cells (red cells, white cells, and platelets)

How to use Mabthera 500

Your doctor or nurse will give you this medicine. Kindly do not self administer.

How Mabthera 500 works

Mabthera 500 is a monoclonal antibody. It works by targeting the unwanted activity of immune cells (B cells) in rheumatoid arthritis and certain types o... View More

What if you forget to take Mabthera 500?

If you miss a dose of Mabthera 500, please consult your doctor.

quick tipsQuick Tips
  • It is given as a drip (intravenous infusion) by your doctor or nurse.
  • You may be given some painkillers, antihistamine and possibly steroids before the drip to help prevent infusion reaction.
  • Your doctor may get blood tests done to check for hepatitis B before treatment and to monitor your blood cells during treatment with this medicine.
  • Inform your doctor immediately if you notice any signs of infection such as fever, sore throat or rash.
  • Inform your doctor if you are pregnant, planning to conceive or breastfeeding.
  • Inform your doctor if you have any heart rhythm problems, if you are having surgery or if you plan to get any vaccinations.
descriptionBrief Description

Indication

Non-Hodgkin's lymphoma; follicular lymphoma

Administration

Reconstitution: Dilute the appropriate dose w/ sodium chloride 0.9% or glucose 5% to a final concentration of between 1 and 4 mg/mL. IV Administratio... View More

Adult Dose

Intravenous Non-Hodgkin Lymphoma Recommended dose for NHL 375 mg/m² IV infusion according to the following schedules Relapsed or refractory low-g... View More

Child Dose

Safety and efficacy not established

Contraindication

Lactation. Type I hypersensitivity or anaphylactic reactions to murine proteins or component of the formulation.

Mode of Action

Rituximab is a chimeric monoclonal antibody to CD20 antigen which regulates cell cycle initiation. It binds to the antigen on the cell surface, activati... View More

Precaution

Extensive tumor burden, pulmonary tumor infiltration or pulmonary insufficiency; history of cardiac disease; effective contraception during and up to 12... View More

Side Effect

>10% NHL Angioedema (11%), hypotension (10%), Asthenia (26%), chills (33%), dizziness (10%), fever (53%), headache (19%) Pruritus (14%), rash (15%), ... View More

Interaction

Increased risk of renal toxicity w/ cisplatin. Potentially Fatal: May decrease the efficacy of vaccines and increase the risk of infections in patien... View More

descriptionDisclaimer

The information provided herein is accurate, updated and complete as per the best practices of the Company. Please note that this information should not... View More