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Palopag 400400mg

Tablet
rx_reqRequire Prescription
Incepta Pharmaceuticals Ltd.
Generic: Selexipag
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descriptionMedical Overview

Indication

Pulmonary Arterial Hypertension

Administration

Swallow tablet whole; do not split, crush, or chew Tolerability may be improved when taken with food Dose interruptions and discontinuations ... View More

Adult Dose

Pulmonary Arterial Hypertension Indicated for pulmonary arterial hypertension (PAH, WHO Group I) to delay disease progression and reduce the risk of ho... View More

Renal Dose

Renal impairment: No dosage adjustment required

Contraindication

Concomitant use of strong CYP2C8 inhibitors (eg, gemfibrozil)

Mode of Action

Selectively activates the prostacyclin receptor (ie, IP-receptor), one of 5 types of prostanoid receptors Unlike prostacyclin analogs, selexipag is sel... View More

Precaution

If signs of pulmonary edema occur, consider the possibility of associated pulmonary veno-occlusive disease (PVOD); if PVOD is confirmed, discontinue sel... View More

Side Effect

>10% Headache (65%) Diarrhea (42%) Jaw pain (26%) Nausea (33%) Vomiting (18%) Pain in extremity (17%) Myalgia (16%) Flushing (12%) Arthralgia (... View More

Interaction

Coadministration with strong CYP2C8 inhibitors may result in a significant increase in exposure to selexipag and its active metabolite Avoid co... View More

descriptionDisclaimer

The information provided herein is accurate, updated and complete as per the best practices of the Company. Please note that this information should not... View More