Delta Pharma Limited
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Caution is advised when consuming alcohol with Methotrax 15. Please consult your doctor.
Methotrax 15 is highly unsafe to use during pregnancy. Seek your doctor's advice as studies on pregnant women and animals have shown significant harmful... View More
Methotrax 15 is unsafe to use during breastfeeding. Data suggests that the drug may cause toxicity to the baby.
Methotrax 15 may decrease alertness, affect your vision or make you feel sleepy and dizzy. Do not drive if these symptoms occur.
Methotrax 15 should be used with caution in patients with kidney disease. Dose adjustment of Methotrax 15 may be needed. Please consult your doctor. Reg... View More
Methotrax 15 should be used with caution in patients with liver disease. Dose adjustment of Methotrax 15 may be needed. Please consult your doctor. Use ... View More
Methotrax 15 is a medicine used to treat rheumatoid arthritis where it can prevent further joint damage. It is also used to treat severe forms of a skin... View More
Uses of Methotrax 15
- Rheumatoid arthritis
Side effects of Methotrax 15
- Abdominal pain
- Loss of appetite
- Mouth sore
How to use Methotrax 15
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Methotrax 15 may be taken ... View More
How Methotrax 15 works
Methotrax 15 is an immunosuppressant. In rheumatoid arthritis, it works by decreasing the activity of the body's immune system. This decreases swelling,... View More
- Take it once a week, on the same day every week.
- Drink plenty of liquids to stay hydrated while taking this medication.
- Always take folic acid as advised by your doctor. This will help lessen the side effects of this medicine.
- It may take 6 to 8 weeks for Methotrax 15 to work. Keep taking the medication as prescribed.
- Avoid drinking alcohol while taking this medicine as it may increase the risk of side effects.
- It can be harmful to an unborn baby. Avoid pregnancy for at least 6 months after your last dose.
Burkitt's lymphoma, Choriocarcinoma, Mycosis fungoides, Crohn's disease, Psoriasis, Osteosarcoma, Breast cancer, lymphosarcoma, Acute lymphoblastic leuk... View More
Should be taken on an empty stomach. Best taken on an empty stomach. May be taken w/ meals to reduce GI discomfort. Avoid taking w/ milk-rich products. ... View More
Adult: PO Burkitt's lymphoma 10-25 mg/day for 4-8 days, repeat after 7-10 days. Choriocarcinoma 15-30 mg/day for 5 days, repeat after an interval ... View More
Polyarticular Juvenile Idiopathic Arthritis Initial: 10 mg/m² PO/IM/SC qWeek Meningeal Leukemia <1 year: 6 mg intrathecally (IT) every 2-5 days 1-... View More
Renal impairment: CrCl (ml/min) Dosage Recommendation 61-80 75% of dose 51-60 70% of dose 10-50 30-50% of dose <10 Avoid use Intermittent hemodi... View More
Severe renal or hepatic impairment, pre-existing profound bone marrow suppression in patients with psoriasis or rheumatoid arthritis, alcoholic liver di... View More
Mode of Action
Methotrexate is a folic acid antagonist that inhibits DNA synthesis. It irreversibly binds to dihydrofolate reductase, inhibiting the formation of reduc... View More
Hepatic or renal impairment, bone marrow depression, elderly, neonates. Ulcerative disorders of the GI tract. Monitor haematological, renal and hepatic ... View More
>10% Arachnoiditis with intrathecal administration,Subacute toxicity with intrathecal administration (paralysis of extremities, cranial nerve palsy, se... View More
Decreased effectiveness with folic acid and its derivatives. Potentially Fatal: Increased toxicity with NSAIDs and salicylates; probenecid; some peni... View More
The information provided herein is accurate, updated and complete as per the best practices of the Company. Please note that this information should not... View More