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Safety Advices
বাংলা
English
CONSULT YOUR DOCTOR
Gynest Cream may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
CONSULT YOUR DOCTOR
Gynest Cream is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.
Medicine Overview of Gynest Cream 0.1% Cream
Introduction
Gynest Cream is identical to a female hormone, estrogen. It is used to treat symptoms associated with menopause. This topical preparation helps to treat vaginal burning, dryness and itching caused due to lack of estrogen. You should use Gynest Cream in the way your doctor advises. It may depend on whether you have had any kind of HRT before. Even if your symptoms improve, you should continue the treatment as it has been prescribed. When you start using this medicine you may experience irritation or itching. This usually goes away if you continue using it. You may also get pain...
... Show moreUses of Gynest Cream
Side effects of Gynest Cream
Common
- Vaginal irritation
How to use Gynest Cream
This medicine is for external use only. Use it in the dose and duration as advised by your doctor. Check the label for directions before use. Clean and dry the affected area and apply the cream by using applicator. Wash your hands after applying.
How Gynest Cream works
Gynest Cream contains oestrogen (female sex hormone). It works by delivering estrogens directly into the vagina to relieve vaginal symptoms of menopause such as dryness, burning, irritation, and painful sexual intercourse.
Quick Tips
- It can be applied to the external vaginal area or inserted into the vagina using the applicator provided.
- It does not expose the rest of your body to the medicine, thereby avoiding side effects that happen more often with pills.
- Do not have sex right after using Gynest Cream as some of the medicine can be absorbed into your partner's skin.
- Inform your doctor if you experience any vaginal bleeding or spotting, abnormal vaginal discharge or vaginal discomfort while using this medicine.
- Do not use Gynest Cream if you are pregnant or breastfeeding, have a history of blood clots or heart diseases.
Brief Description
Indication
Infertility due to cervical hostility, Menopausal atrophic vaginitis, Menopausal hormone replacement therapy, Dyspareunia, Dryness and itching of vagina due to Oestrogen deficiency, Prevention of recurrent infections of the vagina and lower urinary tract, Micturition complaints (such as frequency and dysuria), Urinary incontinence.
Pre- and postoperative therapy in postmenopausal women undergoing vaginal surgery, Climacteric complaints such as hot flushes and night sweating, a diagnostic aid in case of a doubtful atrophic cervical smear.
Administration
Tablet: May be taken with or without food.
Adult Dose
Oral
Menopausal hormone replacement therapy
Adult: 0.5-3 mg daily for 1 mth followed by 0.5-1 mg daily; or 0.25-2 mg daily in combination with other natural oestrogens. A progestogen is required if administered to women with a uterus.
Infertility due to cervical hostility
Adult: 0.25-1 mg/day on days 6-15 of the menstrual cycle. Increase dose each mth until an optimal effect is obtained.
Vaginal
Menopausal atrophic vaginitis
Adult: As cream: Apply 500 mcg once daily, reduce to twice wkly subsequently.
Contraindication
• Pregnancy • Known, past or suspected breast cancer • Known or suspected oestrogen-dependent malignant tumours (e.g. endometrial cancer) • Undiagnosed genital bleeding • Untreated endometrial hyperplasia • Previous idiopathic or current venous thromboembolism (deep venous thrombosis, pulmonary embolism) • Active or recent arterial thromboembolic disease (e.g. angina, myocardial infarction) • Acute liver disease, or a history of liver disease as long as liver function tests failed to return to normal
Mode of Action
Estriol is a naturally occurring oestrogen. It induces normalization of vag epithelium. It is claimed to have only a mild proliferative effect on the endometrium. It only has a short retention time in the nuclei of endometrial cells.
Precaution
In order to prevent endometrial stimulation, the daily dose should not exceed 8 mg nor should this maximum dose be used for longer than several weeks. As for all hormone replacement therapies, yearly medical examination is advisable. With vaginal infections, a concomitant specific treatment is recommended. Patients with any of the following conditions should be monitored; thrombosis, severe liver disorders; porphyria; a history during pregnancy or previous use of steroids of severe pruritus, cholestatic jaundice, herpes gestationis, or otosclerosis.
Side Effect
Breast tension or pain, nausea, spotting. Fluid retention, cervical hypersecretion.
Interaction
Reduced efficacy may occur when used with activated charcoal, barbiturates, carbamazepine, griseofulvin, hydantoin and rifampicin. May possibly change efficacy of oral anticoagulants and increase pharmacologic effects of succinylcholine, theophyllines and troleandromycin.
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