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Acalanib 100100mg

Tablet
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Drug International Ltd.
Generic: Acalabrutinib
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72000.00
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descriptionMedical Overview

Indication

Mantle Cell Lymphoma

Adult Dose

Mantle Cell Lymphoma Indicated for mantle cell lymphoma (MCL) in adults who have received at least 1 prior therapy 100 mg PO q12hr

Mode of Action

Bruton tyrosine kinase (BTK) inhibitor; acalabrutinib and its active metabolite, ACP-5862, form a covalent bond with a cysteine residue in the BTK activ... View More

Precaution

Serious hemorrhagic events, including fatal events, reported; the mechanism for the bleeding events is not well understood; acalabrutinib may further in... View More

Side Effect

>10% All grades Decreased hemoglobin (46%) Decreased platelets (44%) Headache (39%) Decreased neutrophils (36%) Diarrhea (31%) Fatigue (28%) Mya... View More

Pregnancy Category Note

Pregnancy Based on findings in animals, may cause fetal harm when administered to pregnant women There are no available data in pregnant women to in... View More

Interaction

Coadministration with CYP3A inhibitors or inducers Acalabrutinib is predominantly metabolized by CYP3A enzymes CYP3A inhibitors are expected to increa... View More

descriptionDisclaimer

The information provided herein is accurate, updated and complete as per the best practices of the Company. Please note that this information should not... View More