Calcent 100100mg
Tablet
Incepta Pharmaceuticals Ltd.
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Indication
Mantle Cell Lymphoma
Adult Dose
Mantle Cell Lymphoma Indicated for mantle cell lymphoma (MCL) in adults who have received at least 1 prior therapy 100 mg PO q12hr
Mode of Action
Bruton tyrosine kinase (BTK) inhibitor; acalabrutinib and its active metabolite, ACP-5862, form a covalent bond with a cysteine residue in the BTK activ... View More
Precaution
Serious hemorrhagic events, including fatal events, reported; the mechanism for the bleeding events is not well understood; acalabrutinib may further in... View More
Side Effect
>10% All grades Decreased hemoglobin (46%) Decreased platelets (44%) Headache (39%) Decreased neutrophils (36%) Diarrhea (31%) Fatigue (28%) Mya... View More
Pregnancy Category Note
Pregnancy Based on findings in animals, may cause fetal harm when administered to pregnant women There are no available data in pregnant women to in... View More
Interaction
Coadministration with CYP3A inhibitors or inducers Acalabrutinib is predominantly metabolized by CYP3A enzymes CYP3A inhibitors are expected to increa... View More
Alternative brand for Calcent 100
The information provided herein is accurate, updated and complete as per the best practices of the Company. Please note that this information should not... View More