In 30-80% of cases of male subfertility, the most frequent alterations are represented by a reduced quality of spermatozoa which often derives from the harmful effects of oxidative stress. Causes include: Uro-seminal infections, Sources of heat: Tight polyester pants can raise the temperature around the genital area and can affect male fertility, erectile dysfunction, sexually transmitted diseases or surgery. Trauma: trauma and testicular torsions can affect their functionality, Lifestyle: tobacco or cannabis smoke damages the DNA integrity of spermatozoa and reduces their number and motility. There are other risk factors such as male hyperestrogenism, sedentary lifestyle, overweight, obesity, poor diet, alcohol use, Environmental risk: Pesticides, solvents, plastics, paints and radiation can reduce fertility. Oxidative stress is involved in many human diseases, including male infertility. In fact, ROS and oxidative damage levels are higher in infertile men than in fertile ones. ROS cause lipid peroxidation with structural alteration of the acrosome, head and neck region of the spermatozoon and cause apoptosis which induces DNA fragmentation. The correlation between morphological alterations, reduced motility and DNA fragmentation. The concentration of ROS in the sperm is the key to ANTIOXIDANT THERAPIES in the treatment of male infertility caused by oxidative stress. However, it is suggested that use of DIETARY SUPPLEMENTS which act as ADJUVANTS of pharmacological treatments in the treatment of male infertility. SEMYN 100 is a natural aid, thanks to its ingredients.