Cisplatin Hexal PI1mg/2ml

Introduction

Cisplatin Hexal PI is used in the treatment of ovarian, cervical and testicular cancer. It shows its working by stopping or slowing down the growth of c... View More

Uses of Cisplatin Hexal PI

• Ovarian cancer
• Cervical cancer
• Testicular cancer

Side effects of Cisplatin Hexal PI

• Injection site reactions (pain, swelling, redness)
• Increased risk of infection
• Ear disorder
• Vomiting
• Nausea
• Decreased blood cells (red cells, white cells, and platelets)
• Renal impairment
• Peripheral neuropathy (tingling and numbness of feet and hand)
• Kidney damage
• Hearing loss
• Ringing in ear

How to use Cisplatin Hexal PI

Your doctor or nurse will give you this medicine. Kindly do not self-administer.

How Cisplatin Hexal PI works

Cisplatin Hexal PI is an anti-cancer medication. It works by damaging the genetic material (DNA and RNA) of the cancer cells which stops their growth an... View More

What if you forget to take Cisplatin Hexal PI?

If you miss a dose of Cisplatin Hexal PI, please consult your doctor.

Indication

Lymphomas, Sarcomas, Carcinomas, Small cell lung cancer, Ovarian cancer, Germ cell tumors, Metastatic Testicular Tumors, Metastatic Ovarian Tumors, Adva... View More

Administration

IV Preparation Further dilution stability is dependent on chloride ion concentration & should be mixed in solutions of NS (at least 0.3% NaCl) Further... View More

Adult Dose

Metastatic Testicular Tumors Usual dose in combination with other approved chemotherapeutic agents is 20 mg/m²/day IV for 5 days/cycle Pretreatment h... View More

Renal Dose

Renal Impairment CrCl 10-50 mL/min: Decrease dose 50% CrCl <10 mL/min: Contraindicated

Contraindication

Patients with severe renal or auditory disorder, known hypersensitivity, severe bone marrow suppression, peripheral neuropathy, pregnancy, lactation.

Mode of Action

Cisplatin modifies cell cycle by interfering with DNA structure and function. Effects are most prominent during the S phase but cells are killed at all ... View More

Precaution

Patients with renal or hepatic disorder, myelosuppression. Monitor renal, neurological and auditory function. Perform blood counts regularly. Maintain a... View More

Side Effect

>10% Nausea (76-100%),Vomiting (76-100%),Nephrotoxicity (28-36%),Ototoxicity, especially in children (31%),Myelosuppression (25-30%),Anaphylaxis (1-20%... View More

Pregnancy Category Note

Pregnancy Based on human data from published literature, cisplatin can cause fetal harm when administered to pregnant women; data demonstrates transpla... View More

Interaction

Synergistic with 5-fluorouracil and etoposide. Efficacy increased and toxicity reduced when combined with radioprotecting agent WR 2721. At doses ?100 m... View More