Introduction
Clavuran 100 is a combination of two medicines. It is prescribed to treat respiratory tract infections. It treats the infection and prevents further growth and spread of the microorganisms.
Clavuran 100 is a prescription medicine. It is advised to take it as per the prescription. It can be taken with or without food, but it must be taken at a fixed time to ensure better efficacy. Do not consume more than the recommended dose, as this may have harmful effects on your body. If you miss a dose, take it as soon as you remember. The course of the treatment must be completed even if you feel better. Sudden discontinuation of the treatment may affect the potency of the medicine.
Some common side effects of this medicine are nausea, vomiting, diarrhea, indigestion, etc. If any of the side effects get aggravated, you must consult your doctor immediately. If you experience any allergic reaction (rashes, itching, swelling, shortness of breath, etc.), you must seek immediate medical help.
Before taking this medicine, you should tell your doctor if you are taking any medicines for any health condition. Pregnant or breastfeeding women should also consult with their doctor before taking it. Avoid drinking alcohol as it can cause excessive drowsiness with this medicine. It usually does not impair your ability to drive, but you should not drive if it makes you feel sleepy or dizzy. You must take adequate rest for a faster recovery, also take a healthy diet and drink plenty of water. Your doctor may ask for a few laboratory and diagnostic tests to know the effects of the medicine on your body.
Uses of Clavuran 100
- Respiratory tract infection
Side effects of Clavuran 100
Common
- Nausea
- Diarrhea
- Stomach pain
- Headache
How to use Clavuran 100
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Clavuran 100 may be taken with or without food, but it is better to take it at a fixed time.
How Clavuran 100 works
Clavuran 100 is a combination of two medicines: Cefpodoxime Proxetil and Clavulanic Acid. Cefpodoxime Proxetil is an antibiotic. It works by preventing the formation of the bacterial protective covering which is essential for the survival of bacteria. Clavulanic Acid is a beta-lactamase inhibitor which reduces resistance and enhances the activity of Cefpodoxime Proxetil against bacteria.
Indication
Pharyngitis, Acute otitis media, Community-acquired pneumonia, Sinusitis, UTI, Cystitis, Gonorrhea, Skin and skin structure infections, Tonsillitis, Respiratory tract infections, Acute Maxillary Sinusitis, Acute bacterial exacerbation of chronic bronchitis, Enteric fever
Administration
Should be taken with food. Take after meals.
Adult Dose
Acute Bronchitis & Acute Exacerbations of Chronic Bronchitis, Acute Maxillary Sinusitis
200 mg PO q12hr for 10 days
Acute Community-Acquired Pneumonia
200 mg PO q12hr for 14 days
Pharyngitis/Tonsillitis
100 mg PO q12hr for 5-10 days
Skin/Skin Structure Infections
200-400 mg PO q12hr for 7-14 days
Uncomplicated gonorrhoea
200 mg as a single dose
Uncomplicated Urinary Tract Infections
100 mg PO q12hr for 7-14 days
Complicated urinary tract infections
200 mg PO 12 hourly for 7 days
Hepatic impairment
Dosage adjustment not necessary
Child Dose
Child : PO 10 mg/kg/day, max 400 mg/day q12h
6 months - 2 years : 40 mg every 12 hours
3 - 8 years : 80 mg every 12 hours
over 9 years : 100 mg every 12 hours
Renal Dose
Renal impairment: Patients on haemodialysis: Dose should be given after each dialysis session.
CrCl (ml/min) Dosage Recommendation
10-39 Increase dosing intervals to 24 hrly.
<10 Increase dosing intervals to 48 hrly.
Contraindication
Hypersensitivity.
Mode of Action
Cefpodoxime binds to one or more of the penicillin-binding proteins (PBPs) which inhibits the final transpeptidation step of peptidoglycan synthesis in bacterial cell wall, thus inhibiting biosynthesis and arresting cell wall assembly resulting in bacterial cell death.
Addition of clavulanate inhibits beta-lactamase-producing bacteria; Clavulanic acid has a high affinity for and binds to certain ?-lactamases that generally inactivate Cefpodoxime by hydrolyzing its ?-lactam ring. Combining clavulanate potassium with Cefpodoxime extends the antibacterial spectrum of Cefpodoxime to include many bacteria normally resistant to Cefpodoxime and other penicillins and cephalosporins.
Precaution
History of allergy to penicillin; severe renal impairment; pregnancy and lactation.
Lactation: Drug excreted in breast milk in low concentrations; not recommended
Side Effect
>10%
Diarrhea in infants and toddlers (15.4%),Diaper rash (12.1%)
1-10%
Diarrhea (7.4%),Nausea (3.8%),Vaginal infection (3.1%),Vomiting (1.1-2.1%),Abdominal pain (1.6%),Rash (1.4%),Headache (1.1%)
Potentially Fatal: Pseudomembranous colitis; nephrotoxicity.
Interaction
Antacids or H2-blockers may decrease the absorption of cefpodoxime. Reduced renal excretion w/ probenecid.