Clofranil 25 is a tricyclic antidepressant. It is used in adults to treat Obsessive-Compulsive Disorder (OCD). It also treats muscular weakness (cataple... View More
Uses of Clofranil 25
Side effects of Clofranil 25
How to use Clofranil 25
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Clofranil 25 is to be take... View More
How Clofranil 25 works
Clofranil 25 is a tricyclic antidepressant. It increases the levels of chemical messengers in the brain that help in regulating the mood and treat depre... View More
What if you forget to take Clofranil 25?
If you miss a dose of Clofranil 25, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to y... View More
Depression, Panic disorder, Obsessive compulsive disorder, Cataplexy, Narcolepsy, Phobias, Premature ejaculation, Enuresis, Trichotillomania
Should be taken with food.
Oral Adjunct for cataplexy associated with narcolepsy Adult: Initially, 10 mg daily gradually increased to 10-75 mg daily. Elderly: Dose reduction ma... View More
Obsessive-Compulsive Disorder <10 years: Safety and efficacy not established >10 years: 25 mg PO qDay initially Gradually increase to maximum 3 m... View More
Hypersensitivity. Concomitant use of MAOIs; recovery phase following MI, heartblock or other arrhythmias; mania; childn.
Mode of Action
Clomipramine is a potent inhibitor of serotonin re-uptake in the brain. Significant antagonism at cholinergic and ?1-receptors. Weak antagonism at dopam... View More
Cardiovascular insufficiency; narrow-angle glaucoma; urinary retention; history of epilepsy; renal or hepatic dysfunction; electroconvulsive therapy; hy... View More
>10% Xerostomia (84%),Headache (50-55%),Constipation (47%),Ejaculation failure (42%),Fatigue (35-40%),Nausea (30-35%),Impotence (20-25%),Weight gain (1... View More
Pregnancy Category Note
Pregnancy Category: C Lactation: distributed in breast milk, do not nurse (AAP states effect on nursing infants is unknown but may be of concern)
Barbiturates increase metabolism of tricyclic antidepressants; conversely cimetidine, guanethidine, haloperidol and phenothiazines block the tricyclic m... View More
The information provided herein is accurate, updated and complete as per the best practices of the Company. Please note that this information should not... View More